Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AIRE_HUMAN
Description:autoimmune regulator [Source:HGNC Symbol;Acc:360]
Location:chr21 q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S156TASPGsQLKAKPhosphoSitePlus
T183GNGIQtMSASVPhosphoSitePlus
T147APAALtPRGTAPhosphoSitePlus
S187QTMSAsVQRAVPhosphoSitePlus
T68LSWLLtQDSTASp100PhosphoSitePlus

Dephosphorylation site
AIRE_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000291582E51KCOSMICSkin Cancer21984974
ENSP00000291582G369RCOSMICMelanoma21499247

Differential expressed protein
AIRE_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AIRE_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RAF1_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
HASP_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
ITK_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
VRK1_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
STK36_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
AIRE_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0044424intracellular partIEAcellular_component
GO:0045182translation regulator activityIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0008270zinc ion bindingIDAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0003682chromatin bindingIDAmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0015629actin cytoskeletonIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006955immune responseTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0042393histone bindingIDAmolecular_function
GO:0006959humoral immune responseIEAbiological_process


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