| UniProt/SwissProt ID: | AIRE_HUMAN |
| Description: | autoimmune regulator [Source:HGNC Symbol;Acc:360] |
| Location: | chr21 q22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S156 | TASPGsQLKAK | PhosphoSitePlus | |
| T183 | GNGIQtMSASV | PhosphoSitePlus | |
| T147 | APAALtPRGTA | PhosphoSitePlus | |
| S187 | QTMSAsVQRAV | PhosphoSitePlus | |
| T68 | LSWLLtQDSTA | Sp100 | PhosphoSitePlus |
| Dephosphorylation site |
| AIRE_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000291582 | E51K | COSMIC | Skin Cancer | 21984974 | ENSP00000291582 | G369R | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| AIRE_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AIRE_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RAF1_HUMAN | AIRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HASP_HUMAN | AIRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CHK2_HUMAN | AIRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BUB1_HUMAN | AIRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1A_HUMAN | AIRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | AIRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ITK_HUMAN | AIRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| VRK1_HUMAN | AIRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK36_HUMAN | AIRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| AIRE_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0044424 | intracellular part | IEA | cellular_component |
| GO:0045182 | translation regulator activity | IEA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0008270 | zinc ion binding | IDA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0003682 | chromatin binding | IDA | molecular_function |
| GO:0042802 | identical protein binding | IEA | molecular_function |
| GO:0015629 | actin cytoskeleton | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0044212 | transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042393 | histone binding | IDA | molecular_function |
| GO:0006959 | humoral immune response | IEA | biological_process |