Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AGTR1_HUMAN
Description:angiotensin II receptor, type 1 [Source:HGNC Symbol;Acc:336]
Location:chr3 q24
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y319LQLLKyIPPKAPhosphoSitePlus; HPRD; phosphoELM
S335LSTKMsTLSYRPhosphoSitePlus
T332HSNLStKMSTLPhosphoSitePlus
Y26AGRHNyIFVMIPhosphoSitePlus
Y302LNPLFyGFLGKHPRD
T336STKMStLSYRPPhosphoSitePlus
S338KMSTLsYRPSDPhosphoSitePlus

Dephosphorylation site
AGTR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385641G45ABIOMARTBreast Cancer21930507, 21930502
ENSP00000273430D16HBIOMARTBreast Cancer21930507, 21930502
ENSP00000418084D16HBIOMARTBreast Cancer21930507, 21930502
ENSP00000418084A163TBIOMARTGastric Cancer21930507, 21930502
ENSP00000273430G42EBIOMARTBreast Cancer21930507, 21930502
ENSP00000385641G42EBIOMARTBreast Cancer21930507, 21930502
ENSP00000385641D16HBIOMARTBreast Cancer21930507, 21930502
ENSP00000418851G42EBIOMARTBreast Cancer21930507, 21930502
ENSP00000418084G42EBIOMARTBreast Cancer21930507, 21930502
ENSP00000418851G45ABIOMARTBreast Cancer21930507, 21930502
ENSP00000385612G45ABIOMARTBreast Cancer21930507, 21930502
ENSP00000419422G42EBIOMARTBreast Cancer21930507, 21930502
ENSP00000419783D16HBIOMARTBreast Cancer21930507, 21930502
ENSP00000419422G45ABIOMARTBreast Cancer21930507, 21930502
ENSP00000418084G45ABIOMARTBreast Cancer21930507, 21930502
ENSP00000418851D16HBIOMARTBreast Cancer21930507, 21930502
ENSP00000419783G45ABIOMARTBreast Cancer21930507, 21930502
ENSP00000385612D16HBIOMARTBreast Cancer21930507, 21930502
ENSP00000419783G42EBIOMARTBreast Cancer21930507, 21930502
ENSP00000273430G45ABIOMARTBreast Cancer21930507, 21930502
ENSP00000419422D16HBIOMARTBreast Cancer21930507, 21930502
ENSP00000385612G42EBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
AGTR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AGTR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANGT_HUMANAGTR1_HUMANligand -> receptorHPMR
AGTR1_HUMANGNA11_HUMANGPCR -> GproteingpDB
AGTR1_HUMANGNAQ_HUMANGPCR -> GproteingpDB
AGTR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
AGTR1_HUMANGNA12_HUMANGPCR -> GproteingpDB
AGTR1_HUMANGNAI1_HUMANGPCR -> GproteingpDB
AGTR1_HUMANGNAI2_HUMANGPCR -> GproteingpDB
AGTR1_HUMANGNA13_HUMANGPCR -> GproteingpDB
AGTR1_HUMANGNAI3_HUMANGPCR -> GproteingpDB
IP3KA_HUMANAGTR1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04270Vascular smooth muscle contraction
hsa04614Renin-angiotensin system
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0019722calcium-mediated signalingIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIDAbiological_process
GO:0042127regulation of cell proliferationNASbiological_process
GO:0034374low-density lipoprotein particle remodelingNASbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0035813regulation of renal sodium excretionNASbiological_process
GO:0010744positive regulation of macrophage derived foam celICbiological_process
GO:0032270positive regulation of cellular protein metabolic IMPbiological_process
GO:0007266Rho protein signal transductionIDAbiological_process
GO:0010698acetyltransferase activator activityIMPmolecular_function
GO:0001596angiotensin type I receptor activityIDAmolecular_function
GO:0003081regulation of systemic arterial blood pressure by ICbiological_process
GO:0019229regulation of vasoconstrictionICbiological_process
GO:0001822kidney developmentIMPbiological_process
GO:0051482elevation of cytosolic calcium ion concentration iIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0050727regulation of inflammatory responseICbiological_process
GO:0001558regulation of cell growthNASbiological_process
GO:0031711bradykinin receptor bindingIPImolecular_function
GO:0005887integral to plasma membraneICcellular_component
GO:0042312regulation of vasodilationICbiological_process
GO:0060326cell chemotaxisIDAbiological_process
GO:0010873positive regulation of cholesterol esterificationIMPbiological_process
GO:0032430positive regulation of phospholipase A2 activityIMPbiological_process
GO:2000379positive regulation of reactive oxygen species metTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0002034regulation of blood vessel size by renin-angiotensICbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepNASbiological_process
GO:0002018renin-angiotensin regulation of aldosterone producNASbiological_process
GO:0086097phospholipase C-activating angiotensin-mediated siIDAbiological_process
GO:0016021integral to membraneNAScellular_component
GO:0004945angiotensin type II receptor activityIDAmolecular_function
GO:0033864positive regulation of NAD(P)H oxidase activityTASbiological_process
GO:0050729positive regulation of inflammatory responseTASbiological_process