Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VAV3_HUMAN
Description:vav 3 guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:12659]
Location:chr1 p13.3
Node attribute:PPI(target); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y207QTEEKyTETLERhoGEFPhosphoSitePlus
Y173EGGEVyEDLMKPhosphoSitePlus
T131IRPFPtEESINPhosphoSitePlus
Y797IAIARyDFCARSH3_2PhosphoSitePlus
Y217ESIEKyFMAPLRhoGEFPhosphoSitePlus
Y667PKPVDySCQPWFilaminPhosphoSitePlus
S567CGRVNsGEQGTProk-RING_1; FilaminPhosphoSitePlus
S840VGWFPsTYVEESH3_2PhosphoSitePlus
S511PDYADsNFHDFFilaminPhosphoSitePlus
T298DYISKtKEDVKRhoGEFPhosphoSitePlus
T210EKYTEtLESIERhoGEFPhosphoSitePlus
Y294ISSLDyISKTKRhoGEFPhosphoSitePlus
T208TEEKYtETLESRhoGEFPhosphoSitePlus
Y842WFPSTyVEEDESH3_2PhosphoSitePlus
S786GNSLLsPKVLGPhosphoSitePlus
S738NRKFKsLMELVSH2PhosphoSitePlus
Y539LRGTFyQGYLCC1_1; Prok-RING_1; FilamiPhosphoSitePlus
Y141NDEDIyKGLPDPhosphoSitePlus
S134FPTEEsINDEDPhosphoSitePlus
S296SLDYIsKTKEDRhoGEFPhosphoSitePlus
Y818DVVKIyTKMSASH3_2PhosphoSitePlus
S213TETLEsIEKYFRhoGEFPhosphoSitePlus
Y508NIRPDyADSNFFilaminPhosphoSitePlus
T606RNYSGtPPPALSH3_2; FilaminPhosphoSitePlus
Y706KESGEyAISIKSH2; FilaminPhosphoSitePlus

Dephosphorylation site
VAV3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359073Q618EDing2008, COSMICLung Cancer18948947
ENSP00000359073S840YDing2008, COSMICLung Cancer18948947
ENSP00000359073Q385*COSMICBreast Cancer
ENSP00000359073Q385XBIOMARTBreast Cancer21930507, 21930502
ENSP00000359073L758*BIOMARTBreast Cancer21930507, 21930502
ENSP00000394897L198*BIOMARTBreast Cancer21930507, 21930502
ENSP00000359073R38PCOSMICOvarian Cancer21720365
ENSP00000359073E205*COSMICOvarian Cancer21720365

Differential expressed protein
VAV3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
VAV3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ITK_HUMANVAV3_HUMANkinase -> substrateKEGG
KSYK_HUMANVAV3_HUMANkinase -> substrateKEGG
LCP2_HUMANVAV3_HUMANotherKEGG
VAV3_HUMANRHOA_HUMANotherKEGG
VAV3_HUMANPI3R5_HUMANotherKEGG
CD19_HUMANVAV3_HUMANotherKEGG
PI3R5_HUMANVAV3_HUMANotherKEGG
VAV3_HUMANRAC1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04670Leukocyte transendothelial migration
hsa04662B cell receptor signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04660T cell receptor signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04664Fc epsilon RI signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030890positive regulation of B cell proliferationIMPbiological_process
GO:0006906vesicle fusionIEAbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0005154epidermal growth factor receptor bindingIEAmolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005085guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0045785positive regulation of cell adhesionIEAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0030676Rac guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0043552positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0030031cell projection assemblyIEAbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0043547positive regulation of GTPase activityTASbiological_process
GO:0030032lamellipodium assemblyIEAbiological_process
GO:0005096GTPase activator activityTASmolecular_function
GO:0043087regulation of GTPase activityIEAbiological_process
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0050853B cell receptor signaling pathwayIMPbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0042493response to drugIMPbiological_process
GO:0007596blood coagulationTASbiological_process


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