Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:UBB_HUMAN
Description:ubiquitin B [Source:HGNC Symbol;Acc:12463]
Location:chr17 p11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y135RTLSDyNIQKEubiquitin; DUF2870PhosphoSitePlus
T164TLTGKtITLEVubiquitinPhosphoSitePlus
S209DGRTLsDYNIQubiquitinPhosphoSitePlus
T88TLTGKtITLEVubiquitinPhosphoSitePlus
Y211RTLSDyNIQKEubiquitinPhosphoSitePlus
S57DGRTLsDYNIQubiquitin; DUF2870PhosphoSitePlus
S133DGRTLsDYNIQubiquitin; DUF2870PhosphoSitePlus
T83QIFVKtLTGKTubiquitinPhosphoSitePlus
T159QIFVKtLTGKTubiquitinPhosphoSitePlus
T7QIFVKtLTGKTubiquitinPhosphoSitePlus
Y59RTLSDyNIQKEubiquitin; DUF2870PhosphoSitePlus
T12TLTGKtITLEVubiquitinPhosphoSitePlus

Dephosphorylation site
UBB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379178R54CCOSMICMelanoma21499247
ENSP00000379178K48MCOSMICMelanoma21499247

Differential expressed protein
UBB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
UBB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK4_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
UBB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000278mitotic cell cycleTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0000080G1 phase of mitotic cell cycleTASbiological_process
GO:0030666endocytic vesicle membraneTAScellular_component
GO:0016197endosomal transportTASbiological_process
GO:0007144female meiosis IIEAbiological_process
GO:0072520seminiferous tubule developmentIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007254JNK cascadeTASbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0006281DNA repairTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cTASbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0008585female gonad developmentIEAbiological_process
GO:0071456cellular response to hypoxiaTASbiological_process
GO:0010992ubiquitin homeostasisIEAbiological_process
GO:0021888hypothalamus gonadotrophin-releasing hormone neuroIEAbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0060613fat pad developmentIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0002479antigen processing and presentation of exogenous pTASbiological_process
GO:0016044cellular membrane organizationTASbiological_process
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0000209protein polyubiquitinationTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB cascadeTASbiological_process
GO:0097009energy homeostasisIEAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0007141male meiosis IIEAbiological_process
GO:0033554cellular response to stressTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0046788egress of virus within host cellTASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0061418regulation of transcription from RNA polymerase IITASbiological_process
GO:0000122negative regulation of transcription from RNA polyTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 clTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0045944positive regulation of transcription from RNA polyTASbiological_process
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0032480negative regulation of type I interferon productioTASbiological_process
GO:0051436negative regulation of ubiquitin-protein ligase acTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process