Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TGFB1_HUMAN
Description:transforming growth factor, beta 1 [Source:HGNC Symbol;Acc:11766]
Location:chr19 q13.2
Node attribute:PPI(target); PPI(source); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y317HEPKGyHANFCTGF_betaPhosphoSitePlus

Dephosphorylation site
TGFB1_HUMAN do not have dephosphorylation site.

Mutation site
TGFB1_HUMAN do not have mutation site.

Differential expressed protein
TGFB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TGFB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TGFB1_HUMANTGFR1_HUMANotherKEGG
TGFB1_HUMANSMAD2_HUMANotherKEGG
LFTY1_HUMANTGFB1_HUMANotherKEGG
INHBA_HUMANTGFB1_HUMANotherKEGG
TGFB1_HUMANTGFR2_HUMANotherKEGG
LTBP1_HUMANTGFB1_HUMANotherKEGG
PGS2_HUMANTGFB1_HUMANotherKEGG
SP1_HUMANTGFB1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04672Intestinal immune network for IgA production
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05152Tuberculosis
hsa05220Chronic myeloid leukemia
hsa05212Pancreatic cancer
hsa05211Renal cell carcinoma
hsa05144Malaria
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa04110Cell cycle
hsa05210Colorectal cancer
hsa05323Rheumatoid arthritis
hsa05200Pathways in cancer
hsa04144Endocytosis
hsa05414Dilated cardiomyopathy
hsa04060Cytokine-cytokine receptor interaction
hsa05145Toxoplasmosis
hsa05166HTLV-I infection
hsa05146Amoebiasis
hsa04380Osteoclast differentiation
hsa04350TGF-beta signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001934positive regulation of protein phosphorylationIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0009314response to radiationIEAbiological_process
GO:0032270positive regulation of cellular protein metabolic IDAbiological_process
GO:0001933negative regulation of protein phosphorylationIDAbiological_process
GO:0019048virus-host interactionTASbiological_process
GO:0085029extracellular matrix assemblyIEAbiological_process
GO:0046732active induction of host immune response by virusTASbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0006954inflammatory responseISSbiological_process
GO:0070723response to cholesterolIDAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0031575mitotic cell cycle G1/S transition checkpointIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0006796phosphate-containing compound metabolic processIDAbiological_process
GO:0050921positive regulation of chemotaxisIDAbiological_process
GO:0032801receptor catabolic processIDAbiological_process
GO:0007179transforming growth factor beta receptor signalingISSbiological_process
GO:0008284positive regulation of cell proliferationISSbiological_process
GO:0060391positive regulation of SMAD protein import into nuIDAbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0017015regulation of transforming growth factor beta receIDAbiological_process
GO:0043029T cell homeostasisIEAbiological_process
GO:0032570response to progesterone stimulusIDAbiological_process
GO:1901666positive regulation of NAD+ ADP-ribosyltransferaseIDAbiological_process
GO:0005902microvillusIDAcellular_component
GO:0002028regulation of sodium ion transportIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0009611response to woundingIEPbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0002062chondrocyte differentiationIDAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0005796Golgi lumenTAScellular_component
GO:0045786negative regulation of cell cycleIDAbiological_process
GO:0032740positive regulation of interleukin-17 productionIEAbiological_process
GO:0001657ureteric bud developmentIEAbiological_process
GO:0002460adaptive immune response based on somatic recombinIEAbiological_process
GO:0042110T cell activationIEAbiological_process
GO:0048298positive regulation of isotype switching to IgA isIDAbiological_process
GO:0051098regulation of bindingIEAbiological_process
GO:0045662negative regulation of myoblast differentiationIDAbiological_process
GO:0031012extracellular matrixIEAcellular_component
GO:0030308negative regulation of cell growthIEAbiological_process
GO:0007184SMAD protein import into nucleusIEAbiological_process
GO:0042306regulation of protein import into nucleusISSbiological_process
GO:0008156negative regulation of DNA replicationIMPbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0010742macrophage derived foam cell differentiationICbiological_process
GO:0002244hematopoietic progenitor cell differentiationIDAbiological_process
GO:0043932ossification involved in bone remodelingIEPbiological_process
GO:0001763morphogenesis of a branching structureIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0043406positive regulation of MAP kinase activityIDAbiological_process
GO:0060364frontal suture morphogenesisIEAbiological_process
GO:0007183SMAD protein complex assemblyIDAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0042306regulation of protein import into nucleusIEAbiological_process
GO:0031100organ regenerationIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0019058viral infectious cycleTASbiological_process
GO:0002248connective tissue replacement involved in inflammaTASbiological_process
GO:0031536positive regulation of exit from mitosisIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0043499eukaryotic cell surface bindingIMPmolecular_function
GO:0060389pathway-restricted SMAD protein phosphorylationIEAbiological_process
GO:0043011myeloid dendritic cell differentiationIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0048535lymph node developmentISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005578proteinaceous extracellular matrixISScellular_component
GO:0042060wound healingIEAbiological_process
GO:0006917induction of apoptosisIDAbiological_process
GO:0005114type II transforming growth factor beta receptor bIDAmolecular_function
GO:0030217T cell differentiationIEAbiological_process
GO:0016202regulation of striated muscle tissue developmentISSbiological_process
GO:0061035regulation of cartilage developmentIEAbiological_process
GO:0048565digestive tract developmentIEAbiological_process
GO:0047485protein N-terminus bindingIEAmolecular_function
GO:0006754ATP biosynthetic processIDAbiological_process
GO:0010575positive regulation vascular endothelial growth faTASbiological_process
GO:0030501positive regulation of bone mineralizationIEPbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0022408negative regulation of cell-cell adhesionIDAbiological_process
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0051897positive regulation of protein kinase B signaling IDAbiological_process
GO:0043491protein kinase B signaling cascadeIMPbiological_process
GO:0032943mononuclear cell proliferationIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0060325face morphogenesisIEAbiological_process
GO:0031065positive regulation of histone deacetylationIEAbiological_process
GO:0051280negative regulation of release of sequestered calcIEAbiological_process
GO:2000679positive regulation of transcription regulatory reIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0010862positive regulation of pathway-restricted SMAD proIDAbiological_process
GO:0007565female pregnancyIEAbiological_process
GO:0001775cell activationIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0030279negative regulation of ossificationIEAbiological_process
GO:0060744mammary gland branching involved in thelarcheIEAbiological_process
GO:0060389pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0001837epithelial to mesenchymal transitionIEAbiological_process
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0042552myelinationIEAbiological_process
GO:0008219cell deathIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0060751branch elongation involved in mammary gland duct bIEAbiological_process
GO:0051101regulation of DNA bindingISSbiological_process
GO:0071549cellular response to dexamethasone stimulusIEAbiological_process
GO:0032355response to estradiol stimulusIDAbiological_process
GO:0006611protein export from nucleusIDAbiological_process
GO:0045599negative regulation of fat cell differentiationIDAbiological_process
GO:0070306lens fiber cell differentiationIEAbiological_process
GO:0032740positive regulation of interleukin-17 productionIDAbiological_process
GO:0030424axonIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0035307positive regulation of protein dephosphorylationIDAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayIDAbiological_process
GO:0045216cell-cell junction organizationIDAbiological_process
GO:0002513tolerance induction to self antigenIEAbiological_process
GO:0051098regulation of bindingISSbiological_process
GO:0009817defense response to fungus, incompatible interactiIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0051152positive regulation of smooth muscle cell differenIEAbiological_process
GO:0040007growthIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0043536positive regulation of blood vessel endothelial ceIDAbiological_process
GO:0032967positive regulation of collagen biosynthetic proceIEAbiological_process
GO:0050777negative regulation of immune responseIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0032930positive regulation of superoxide anion generationIDAbiological_process
GO:0007184SMAD protein import into nucleusIDAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0050868negative regulation of T cell activationIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0085029extracellular matrix assemblyIDAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIEAbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tIEAbiological_process
GO:0034616response to laminar fluid shear stressIEAbiological_process
GO:0050714positive regulation of protein secretionIDAbiological_process
GO:0090190positive regulation of branching involved in ureteIEAbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0016049cell growthIEAbiological_process
GO:0030214hyaluronan catabolic processIDAbiological_process
GO:0030334regulation of cell migrationTASbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0033280response to vitamin DIEAbiological_process
GO:0031334positive regulation of protein complex assemblyIDAbiological_process
GO:0042482positive regulation of odontogenesisIEAbiological_process
GO:0048535lymph node developmentIEAbiological_process
GO:0007406negative regulation of neuroblast proliferationIEAbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tIDAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0002576platelet degranulationTASbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0060762regulation of branching involved in mammary gland IEAbiological_process
GO:0010800positive regulation of peptidyl-threonine phosphorIDAbiological_process
GO:0019049evasion or tolerance of host defenses by virusIDAbiological_process
GO:0008354germ cell migrationIEAbiological_process
GO:0050765negative regulation of phagocytosisIEAbiological_process
GO:0071158positive regulation of cell cycle arrestIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0030141secretory granuleIEAcellular_component
GO:0006954inflammatory responseIEAbiological_process
GO:0045066regulatory T cell differentiationIEAbiological_process
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0010936negative regulation of macrophage cytokine productIDAbiological_process
GO:0007492endoderm developmentIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0007435salivary gland morphogenesisIEPbiological_process
GO:0042307positive regulation of protein import into nucleusIDAbiological_process
GO:0000165MAPK cascadeIMPbiological_process
GO:0007568agingIEAbiological_process
GO:0043537negative regulation of blood vessel endothelial ceIDAbiological_process
GO:0032967positive regulation of collagen biosynthetic proceIMPbiological_process
GO:0042130negative regulation of T cell proliferationIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0071407cellular response to organic cyclic compoundIDAbiological_process
GO:0007050cell cycle arrestIDAbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0035066positive regulation of histone acetylationIEAbiological_process
GO:0051101regulation of DNA bindingIEAbiological_process
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0000060protein import into nucleus, translocationIDAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIMPbiological_process
GO:1900126negative regulation of hyaluronan biosynthetic proIDAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0016202regulation of striated muscle tissue developmentIEAbiological_process
GO:0010763positive regulation of fibroblast migrationIDAbiological_process
GO:0006468protein phosphorylationISSbiological_process
GO:0048642negative regulation of skeletal muscle tissue deveIDAbiological_process
GO:0045930negative regulation of mitotic cell cycleIDAbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component