| UniProt/SwissProt ID: | LTBP1_HUMAN |
| Description: | latent transforming growth factor beta binding protein 1 [Source:HGNC Symbol;Acc:6714] |
| Location: | chr2 p22.3 |
| Node attribute: | PPI(target); PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y1600 | DFSEQyTPEAD | PhosphoSitePlus | |
| Y1599 | VDFSEqYTPEA | HPRD | |
| Y1273 | VDFSEqYTPEA | HPRD | |
| T1601 | FSEQYtPEADP | PhosphoSitePlus | |
| S1596 | DALVDfSEQYT | HPRD | |
| T1600 | DFSEQyTPEAD | HPRD | |
| Y1688 | NTDGSyKCLCL | EGF_CA | PhosphoSitePlus |
| Y904 | ICYEGyRFSEQ | EGF; EGF_CA | PhosphoSitePlus |
| T897 | LPVRYtCICYE | EGF_CA | PhosphoSitePlus |
| Y523 | QSQVSyQGLPV | EGF_CA | PhosphoSitePlus |
| T991 | SGYRMtQRGRC | EGF_CA | PhosphoSitePlus |
| T531 | LPVQKtQTIHS | EGF_CA | PhosphoSitePlus |
| Y901 | YTCICyEGYRF | EGF; EGF_CA | PhosphoSitePlus |
| S1413 | VPAGEsSSEAG | TB | PhosphoSitePlus |
| S1597 | ALVDFsEQYTP | PhosphoSitePlus | |
| T1274 | DFSEQyTPEAD | HPRD | |
| S1270 | DALVDfSEQYT | HPRD | |
| Y896 | NLPVRyTCICY | EGF; EGF_CA | PhosphoSitePlus |
| Dephosphorylation site |
| LTBP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000384091 | D1245N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000346467 | T213A | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000386043 | A1574P | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000346467 | A1575P | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000386043 | T213A | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000384091 | G1229E | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000385359 | A1195P | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000384091 | A1248P | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000374653 | A1249P | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| LTBP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LTBP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| COMP_HUMAN | LTBP1_HUMAN | other | KEGG |
| LTBP1_HUMAN | TGFB1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04350 | TGF-beta signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031012 | extracellular matrix | IDA | cellular_component |
| GO:0035583 | sequestering of TGFbeta in extracellular matrix | TAS | biological_process |
| GO:0019838 | growth factor binding | IEA | molecular_function |
| GO:0005578 | proteinaceous extracellular matrix | NAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0005578 | proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005024 | transforming growth factor beta-activated receptor | NAS | molecular_function |