| UniProt/SwissProt ID: | LFTY1_HUMAN |
| Description: | left-right determination factor 1 [Source:HGNC Symbol;Acc:6552] |
| Location: | chr1 q42.12 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| LFTY1_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| LFTY1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000272134 | F82L | COSMIC | Skin Cancer | 21984974 | ENSP00000272134 | G70E | COSMIC | Head and Neck Cancer | 21984974 |
| Differential expressed protein |
| LFTY1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LFTY1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LFTY1_HUMAN | NODAL_HUMAN | other | KEGG |
| LFTY1_HUMAN | TGFB1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04350 | TGF-beta signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0040007 | growth | IEA | biological_process |
| GO:0007179 | transforming growth factor beta receptor signaling | TAS | biological_process |
| GO:0007368 | determination of left/right symmetry | ISS | biological_process |
| GO:0008083 | growth factor activity | IEA | molecular_function |
| GO:0005160 | transforming growth factor beta receptor binding | IEA | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | ISS | biological_process |
| GO:0016049 | cell growth | IEA | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0003007 | heart morphogenesis | ISS | biological_process |
| GO:0005125 | cytokine activity | IEA | molecular_function |