UniProt/SwissProt ID: | PGS2_HUMAN |
Description: | decorin [Source:HGNC Symbol;Acc:2705] |
Location: | chr12 q21.33 |
Node attribute: | PPI(source) |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S328 | SYSGVsLFSNP | PhosphoSitePlus | |
T126 | SPGAFtPLVKL | PhosphoSitePlus | |
Dephosphorylation site |
PGS2_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000052754 | Q217* | COSMIC | Central Nervous System Neoplasms | 18772890 |
ENSP00000447654 | Q217* | COSMIC | Central Nervous System Neoplasms | 18772890 |
ENSP00000376862 | R133* | COSMIC | Central Nervous System Neoplasms | 18772890 |
ENSP00000447654 | R133* | COSMIC | Central Nervous System Neoplasms | 18772890 |
ENSP00000052754 | N255K | COSMIC | Lung Cancer | |
ENSP00000376862 | N255K | COSMIC | Lung Cancer | |
ENSP00000376862 | Q217* | COSMIC | Central Nervous System Neoplasms | 18772890 |
ENSP00000447654 | N255K | COSMIC | Lung Cancer | |
ENSP00000052754 | R133* | COSMIC | Central Nervous System Neoplasms | 18772890 |
Differential expressed protein |
Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
---|---|---|---|---|---|---|
ENSP00000376862 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.82 | 20739354 |
ENSP00000376862 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.82 | 20739354 |
ENSP00000376862 | Ovarian Cancer | Treatment (chemotherapy-sensitive vs. chemotherapy-resistant) | tissue | Up | 5.5 | 19422301 |
ENSP00000376862 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 2.6 | 16230073 |
ENSP00000376862 | Gastric Cancer | Normal vs. Cancer | cell line | Down | 0.11 | 20812763 |
ENSP00000376862 | Gastric Cancer | Normal vs. Cancer | cell line | Down | 0.07 | 20812763 |
Hyperphosphorylation site |
PGS2_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
PGS2_HUMAN | TGFB1_HUMAN | other | KEGG |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04350 | TGF-beta signaling pathway |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0005578 | proteinaceous extracellular matrix | IEA | cellular_component |
GO:0005796 | Golgi lumen | TAS | cellular_component |
GO:0030204 | chondroitin sulfate metabolic process | TAS | biological_process |
GO:0007568 | aging | IEA | biological_process |
GO:0007519 | skeletal muscle tissue development | IEA | biological_process |
GO:0044281 | small molecule metabolic process | TAS | biological_process |
GO:0019800 | peptide cross-linking via chondroitin 4-sulfate gl | IEA | biological_process |
GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
GO:0001890 | placenta development | IEA | biological_process |
GO:0043202 | lysosomal lumen | TAS | cellular_component |
GO:0042060 | wound healing | IEA | biological_process |
GO:0050840 | extracellular matrix binding | IEA | molecular_function |
GO:0030208 | dermatan sulfate biosynthetic process | TAS | biological_process |
GO:0001822 | kidney development | IEA | biological_process |
GO:0030206 | chondroitin sulfate biosynthetic process | TAS | biological_process |
GO:0009887 | organ morphogenesis | TAS | biological_process |
GO:0005615 | extracellular space | IDA | cellular_component |
GO:0005589 | collagen type VI | IEA | cellular_component |
GO:0032496 | response to lipopolysaccharide | IEA | biological_process |
GO:0005518 | collagen binding | IEA | molecular_function |
GO:0005539 | glycosaminoglycan binding | IEA | molecular_function |
GO:0005515 | protein binding | IEA | molecular_function |
GO:0009612 | response to mechanical stimulus | IEA | biological_process |
GO:0031012 | extracellular matrix | IDA | cellular_component |
GO:0005576 | extracellular region | TAS | cellular_component |
GO:0030207 | chondroitin sulfate catabolic process | TAS | biological_process |
GO:0030203 | glycosaminoglycan metabolic process | TAS | biological_process |
GO:0047485 | protein N-terminus binding | IEA | molecular_function |