Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PGS2_HUMAN
Description:decorin [Source:HGNC Symbol;Acc:2705]
Location:chr12 q21.33
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S328SYSGVsLFSNPPhosphoSitePlus
T126SPGAFtPLVKLPhosphoSitePlus

Dephosphorylation site
PGS2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000052754Q217*COSMICCentral Nervous System Neoplasms18772890
ENSP00000447654Q217*COSMICCentral Nervous System Neoplasms18772890
ENSP00000376862R133*COSMICCentral Nervous System Neoplasms18772890
ENSP00000447654R133*COSMICCentral Nervous System Neoplasms18772890
ENSP00000052754N255KCOSMICLung Cancer
ENSP00000376862N255KCOSMICLung Cancer
ENSP00000376862Q217*COSMICCentral Nervous System Neoplasms18772890
ENSP00000447654N255KCOSMICLung Cancer
ENSP00000052754R133*COSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000376862Breast CancerNormal vs. CancertissueDown0.8220739354
ENSP00000376862Breast CancerNormal vs. CancertissueDown0.8220739354
ENSP00000376862Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueUp5.519422301
ENSP00000376862Pancreatic CancerNormal vs. CancertissueUp2.616230073
ENSP00000376862Gastric CancerNormal vs. Cancercell lineDown0.1120812763
ENSP00000376862Gastric CancerNormal vs. Cancercell lineDown0.0720812763

Hyperphosphorylation site
PGS2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PGS2_HUMANTGFB1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04350TGF-beta signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0030204chondroitin sulfate metabolic processTASbiological_process
GO:0007568agingIEAbiological_process
GO:0007519skeletal muscle tissue developmentIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0019800peptide cross-linking via chondroitin 4-sulfate glIEAbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0001890placenta developmentIEAbiological_process
GO:0043202lysosomal lumenTAScellular_component
GO:0042060wound healingIEAbiological_process
GO:0050840extracellular matrix bindingIEAmolecular_function
GO:0030208dermatan sulfate biosynthetic processTASbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0030206chondroitin sulfate biosynthetic processTASbiological_process
GO:0009887organ morphogenesisTASbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0005589collagen type VIIEAcellular_component
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0005518collagen bindingIEAmolecular_function
GO:0005539glycosaminoglycan bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0005576extracellular regionTAScellular_component
GO:0030207chondroitin sulfate catabolic processTASbiological_process
GO:0030203glycosaminoglycan metabolic processTASbiological_process
GO:0047485protein N-terminus bindingIEAmolecular_function


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