Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PERF_HUMAN
Description:perforin 1 (pore forming protein) [Source:HGNC Symbol;Acc:9360]
Location:chr10 q22.1
Node attribute:gene

Phosphorylation site
PERF_HUMAN do not have phosphorylation site.

Dephosphorylation site
PERF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362305R123HCOSMICIntestines Cancer16959974
ENSP00000316746R123HBIOMARTColorectal Cancer21930507, 21930502
ENSP00000362305N252SOMIMLymphoma15459303 15659737 15659737 15728124
ENSP00000362305*556CCOSMICOvarian Cancer21720365
ENSP00000362305R123HSjoblom2006Intestines Cancer16959974
ENSP00000398568A91VOMIMLymphoma12229880 15728124 15755897 17475905
ENSP00000398568N252SOMIMLymphoma15459303 15659737 15659737 15728124
ENSP00000316746*556CCOSMICOvarian Cancer21720365
ENSP00000362305R385WCOSMICCentral Nervous System Neoplasms18772890
ENSP00000316746N252SOMIMLymphoma15459303 15659737 15659737 15728124
ENSP00000316746A91VOMIMLymphoma12229880 15728124 15755897 17475905
ENSP00000398568*556CCOSMICOvarian Cancer21720365
ENSP00000362305A91VOMIMLymphoma12229880 15728124 15755897 17475905

Differential expressed protein
PERF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PERF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STAT4_HUMANPERF_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
PERF_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031904endosome lumenIEAcellular_component
GO:0005509calcium ion bindingISSmolecular_function
GO:0006968cellular defense responseTASbiological_process
GO:0019835cytolysisIEAbiological_process
GO:0022829wide pore channel activityIEAmolecular_function
GO:0051260protein homooligomerizationIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0002357defense response to tumor cellIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051260protein homooligomerizationIDAbiological_process
GO:0002418immune response to tumor cellISSbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0051607defense response to virusIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0022829wide pore channel activityIDAmolecular_function
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0051607defense response to virusISSbiological_process
GO:0002357defense response to tumor cellISSbiological_process
GO:0019835cytolysisISSbiological_process
GO:0016021integral to membraneIDAcellular_component
GO:0044194cytolytic granuleISScellular_component
GO:0002418immune response to tumor cellIEAbiological_process
GO:0044194cytolytic granuleIEAcellular_component
GO:0016021integral to membraneIEAcellular_component