| UniProt/SwissProt ID: | SOMA_HUMAN |
| Description: | growth hormone 1 [Source:HGNC Symbol;Acc:4261] |
| Location: | chr17 q23.3 |
| Node attribute: | PPI(source); ligand; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T93 | SNREEtQQKSN | Hormone_1 | PhosphoSitePlus |
| S176 | KFDTNsHNDDA | Hormone_1 | PhosphoSitePlus |
| Y68 | PKEQKySFLQN | Hormone_1 | PhosphoSitePlus |
| S132 | LVYGAsDSNVY | HPRD; phosphoELM | |
| S176 | KFDTNsHNDDA | HPRD; phosphoELM | |
| S132 | LVYGAsDSNVY | Hormone_1 | PhosphoSitePlus |
| S97 | ETQQKsNLELL | Hormone_1 | PhosphoSitePlus |
| S161 | KFDTNsHNDDA | HPRD | |
| S77 | QNPQTsLCFSE | Hormone_1 | PhosphoSitePlus |
| S117 | LVYGAsDSNVY | HPRD | |
| S77 | QNPQTsLCFSE | phosphoELM | |
| Dephosphorylation site |
| SOMA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000408486 | *203L | COSMIC | Hepatocellular Carcinoma | 21822264 |
| Differential expressed protein |
| SOMA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SOMA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SOMA_HUMAN | GHR_HUMAN | ligand -> receptor | HPMR |
| SOMA_HUMAN | GHR_HUMAN | other | KEGG |
| SP1_HUMAN | SOMA_HUMAN | TF -> target gene | TRANSFAC |
| PIT1_HUMAN | SOMA_HUMAN | TF -> target gene | TRANSFAC |
| VDR_HUMAN | SOMA_HUMAN | TF -> target gene | TRANSFAC |
| AP2A_HUMAN | SOMA_HUMAN | TF -> target gene | TRANSFAC |
| NFIC_HUMAN | SOMA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005131 | growth hormone receptor binding | IPI | molecular_function |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kina | IDA | biological_process |
| GO:0005148 | prolactin receptor binding | IPI | molecular_function |
| GO:0032355 | response to estradiol stimulus | IDA | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0060396 | growth hormone receptor signaling pathway | IDA | biological_process |
| GO:0070977 | bone maturation | IDA | biological_process |
| GO:0015758 | glucose transport | IDA | biological_process |
| GO:0046427 | positive regulation of JAK-STAT cascade | IDA | biological_process |
| GO:0043568 | positive regulation of insulin-like growth factor | IDA | biological_process |
| GO:0060397 | JAK-STAT cascade involved in growth hormone signal | TAS | biological_process |
| GO:0007259 | JAK-STAT cascade | IDA | biological_process |
| GO:0040018 | positive regulation of multicellular organism grow | IDA | biological_process |
| GO:0042523 | positive regulation of tyrosine phosphorylation of | IDA | biological_process |
| GO:0042517 | positive regulation of tyrosine phosphorylation of | IDA | biological_process |
| GO:0043406 | positive regulation of MAP kinase activity | TAS | biological_process |
| GO:0010535 | positive regulation of activation of JAK2 kinase a | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphory | IDA | biological_process |
| GO:0005179 | hormone activity | IEA | molecular_function |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0008083 | growth factor activity | IPI | molecular_function |