Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SOCS3_HUMAN
Description:suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:19391]
Location:chr17 q25.3
Node attribute:PPI(source); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y165PPRRAyYIYSGPhosphoSitePlus
Y221EFLDQyDAPLLckRegPhos
Y221EFLDQyDAphosphoELM
Y221EFLDQyDAPL_SOCS_boxPhosphoSitePlus
Y204GHLDSyEKVTQLckphosphoELM; RegPhos
Y204GHLDSyEKVTQSOCS_boxPhosphoSitePlus
Y221EFLDQyDALckphosphoELM
Y166PRRAYyIYSGGPhosphoSitePlus

Dephosphorylation site
SOCS3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000330341*226YCOSMICOvarian Cancer21720365
ENSP00000330341R94LCOSMICOvarian Cancer20826764

Differential expressed protein
SOCS3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SOCS3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LCK_HUMANSOCS3_HUMANkinase -> substrateRobert H Newman (2013)
JAK3_HUMANSOCS3_HUMANkinase -> substrateNetPath
JAK1_HUMANSOCS3_HUMANkinase -> substrateNetPath
SOCS3_HUMANJAK2_HUMANotherKEGG
SOCS3_HUMANIRS1_HUMANotherKEGG
SOCS3_HUMANOBRG_HUMANotherKEGG
STAT3_HUMANSOCS3_HUMANTF -> target geneKEGG
NFKB1_HUMANSOCS3_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway
hsa05168Herpes simplex infection
hsa05164Influenza A
hsa04120Ubiquitin mediated proteolysis
hsa05160Hepatitis C
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04380Osteoclast differentiation
hsa04930Type II diabetes mellitus

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0001932regulation of protein phosphorylationIEAbiological_process
GO:0016567protein ubiquitinationIEAbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0045595regulation of cell differentiationIEAbiological_process
GO:0060670branching involved in labyrinthine layer morphogenIEAbiological_process
GO:0006469negative regulation of protein kinase activityTASbiological_process
GO:0009968negative regulation of signal transductionIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0060334regulation of interferon-gamma-mediated signaling TASbiological_process
GO:0060674placenta blood vessel developmentIEAbiological_process
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0060708spongiotrophoblast differentiationIEAbiological_process
GO:0004860protein kinase inhibitor activityTASmolecular_function
GO:0060338regulation of type I interferon-mediated signalingTASbiological_process
GO:0046627negative regulation of insulin receptor signaling IEAbiological_process
GO:0060707trophoblast giant cell differentiationIEAbiological_process
GO:0040008regulation of growthIEAbiological_process


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