| UniProt/SwissProt ID: | SOCS3_HUMAN |
| Description: | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:19391] |
| Location: | chr17 q25.3 |
| Node attribute: | PPI(source); substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y165 | PPRRAyYIYSG | PhosphoSitePlus | |
| Y221 | EFLDQyDAPL | Lck | RegPhos |
| Y221 | EFLDQyDA | phosphoELM | |
| Y221 | EFLDQyDAPL_ | SOCS_box | PhosphoSitePlus |
| Y204 | GHLDSyEKVTQ | Lck | phosphoELM; RegPhos |
| Y204 | GHLDSyEKVTQ | SOCS_box | PhosphoSitePlus |
| Y221 | EFLDQyDA | Lck | phosphoELM |
| Y166 | PRRAYyIYSGG | PhosphoSitePlus | |
| Dephosphorylation site |
| SOCS3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000330341 | *226Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000330341 | R94L | COSMIC | Ovarian Cancer | 20826764 |
| Differential expressed protein |
| SOCS3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SOCS3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LCK_HUMAN | SOCS3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| JAK3_HUMAN | SOCS3_HUMAN | kinase -> substrate | NetPath |
| JAK1_HUMAN | SOCS3_HUMAN | kinase -> substrate | NetPath |
| SOCS3_HUMAN | JAK2_HUMAN | other | KEGG |
| SOCS3_HUMAN | IRS1_HUMAN | other | KEGG |
| SOCS3_HUMAN | OBRG_HUMAN | other | KEGG |
| STAT3_HUMAN | SOCS3_HUMAN | TF -> target gene | KEGG |
| NFKB1_HUMAN | SOCS3_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| hsa05168 | Herpes simplex infection |
| hsa05164 | Influenza A |
| hsa04120 | Ubiquitin mediated proteolysis |
| hsa05160 | Hepatitis C |
| hsa04910 | Insulin signaling pathway |
| hsa04920 | Adipocytokine signaling pathway |
| hsa04380 | Osteoclast differentiation |
| hsa04930 | Type II diabetes mellitus |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045597 | positive regulation of cell differentiation | IEA | biological_process |
| GO:0001932 | regulation of protein phosphorylation | IEA | biological_process |
| GO:0016567 | protein ubiquitination | IEA | biological_process |
| GO:0060333 | interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0060397 | JAK-STAT cascade involved in growth hormone signal | TAS | biological_process |
| GO:0007259 | JAK-STAT cascade | TAS | biological_process |
| GO:0045595 | regulation of cell differentiation | IEA | biological_process |
| GO:0060670 | branching involved in labyrinthine layer morphogen | IEA | biological_process |
| GO:0006469 | negative regulation of protein kinase activity | TAS | biological_process |
| GO:0009968 | negative regulation of signal transduction | IEA | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0060337 | type I interferon-mediated signaling pathway | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0060334 | regulation of interferon-gamma-mediated signaling | TAS | biological_process |
| GO:0060674 | placenta blood vessel development | IEA | biological_process |
| GO:0043066 | negative regulation of apoptotic process | TAS | biological_process |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0060708 | spongiotrophoblast differentiation | IEA | biological_process |
| GO:0004860 | protein kinase inhibitor activity | TAS | molecular_function |
| GO:0060338 | regulation of type I interferon-mediated signaling | TAS | biological_process |
| GO:0046627 | negative regulation of insulin receptor signaling | IEA | biological_process |
| GO:0060707 | trophoblast giant cell differentiation | IEA | biological_process |
| GO:0040008 | regulation of growth | IEA | biological_process |