Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SMRC2_HUMAN
Description:SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 [Source:HGNC Symbol;Acc:11105]
Location:chr12 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S321AKKGPsTPYTKPhosphoSitePlus; HPRD
T579NFGLRtDMYTKPhosphoSitePlus
S399DEDENsTGNKGPhosphoSitePlus; HPRD
T308PSPSPtPEAKKPhosphoSitePlus; HPRD
T400EDENStGNKGEPhosphoSitePlus
S841DSEKEsEKSDGHPRD
S555QQTSAsQQMLNPhosphoSitePlus
T322KKGPStPYTKSPhosphoSitePlus; HPRD
S304RKRSPsPSPTPPhosphoSitePlus; HPRD; phosphoELM
S841KEVVEsEGERKPhosphoSitePlus; HPRD
S844KESEKsDGDPIHPRD
T1124SPGTVtPVPPHPRD
T726EAAKVtGKADPPhosphoSitePlus
Y324GPSTPyTKSKRPhosphoSitePlus
T583RTDMYtKKNVPPhosphoSitePlus
S102AYKFKsDQGWRPhosphoSitePlus; HPRD
T390DESMEtTGKDEPhosphoSitePlus
S369KKDSEsAPVKGPhosphoSitePlus
S387EQEDEsMETTGPhosphoSitePlus
Y582LRTDMyTKKNVPhosphoSitePlus
T548PLQPKtPQQTSPhosphoSitePlus; HPRD; phosphoELM
S302KKRKRsPSPSPPhosphoSitePlus; HPRD; phosphoELM
T378KGGTMtDLDEQPhosphoSitePlus
S283TDEVNsPDSDRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S969ALPPGsQPIPPPhosphoSitePlus
Y941MEQLKyAEMRAPhosphoSitePlus
Y296KKGGNyKKRKRHPRD
T1208SPGTVtPVPPHPRD
Y465EIYLAyRNFMIHPRD
S553TPQQTsASQQMPhosphoSitePlus
S286VNSPDsDRRDKPhosphoSitePlus; HPRD; phosphoELM
S837GKEGDsEKESEHPRD
S813KESEKsDGDPIPhosphoSitePlus; HPRD
S872KEVVEsEGERKHPRD
S347DMDEPsPVPNVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S695SAAAKsALEEFPhosphoSitePlus
S810DSEKEsEKSDGHPRD
S806GKEGDsEKESEPhosphoSitePlus; HPRD
S306RSPSPsPTPEAPhosphoSitePlus; HPRD
T376PVKGGtMTDLDPhosphoSitePlus

Dephosphorylation site
SMRC2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000267064Q478LCOSMICOvarian Cancer21720365
ENSP00000267064D471HBIOMARTBreast Cancer21930507, 21930502
ENSP00000302919D471HBIOMARTBreast Cancer21930507, 21930502
ENSP00000267064F700LCOSMICHead and Neck Cancer21798893
ENSP00000267064I901MCOSMICLung Cancer
ENSP00000267064R329CCOSMICCentral Nervous System Neoplasms18772396
ENSP00000267064E614KCOSMICMelanoma
ENSP00000267064E419*COSMICSkin Cancer21984974

Differential expressed protein
SMRC2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SMRC2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK7_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SMRC2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071564npBAF complexIEAcellular_component
GO:0007399nervous system developmentIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0006338chromatin remodelingIDAbiological_process
GO:0003713transcription coactivator activityNASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006357regulation of transcription from RNA polymerase IINASbiological_process
GO:0017053transcriptional repressor complexIPIcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0071565nBAF complexIEAcellular_component
GO:0006337nucleosome disassemblyIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0016514SWI/SNF complexIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process