| UniProt/SwissProt ID: | S1PR5_HUMAN |
| Description: | sphingosine-1-phosphate receptor 5 [Source:HGNC Symbol;Acc:14299] |
| Location: | chr19 p13.2 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S299 | LAMANsLLNPI | 7tm_1; TM | PhosphoSitePlus |
| T309 | IIYTLtNRDLR | PhosphoSitePlus | |
| Y216 | LYARIyCQVRA | 7tm_1 | PhosphoSitePlus |
| S146 | GPAPVsSRGRT | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| S1PR5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000328472 | D374N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000328472 | R370H | COSMIC | Pancreatic Cancer |
| Differential expressed protein |
| S1PR5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| S1PR5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| S1PR5_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR5_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR5_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR5_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR5_HUMAN | GNA13_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR5_HUMAN | GNA12_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0038036 | sphingosine-1-phosphate receptor activity | IEA | molecular_function |
| GO:0045664 | regulation of neuron differentiation | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |