| UniProt/SwissProt ID: | RD23B_HUMAN |
| Description: | RAD23 homolog B (S. cerevisiae) [Source:HGNC Symbol;Acc:9813] |
| Location: | chr9 q31.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T159 | ETPVAtSPTAT | HPRD | |
| S297 | IQQNPsLLPAL | XPC-binding | PhosphoSitePlus |
| T164 | TSPTAtDSTSG | KAR9 | PhosphoSitePlus |
| S160 | TPVATsPTATD | HPRD; phosphoELM; SysPTM | |
| T162 | VATSPtATDST | KAR9 | PhosphoSitePlus; SysPTM |
| S160 | TPVATsPTATD | KAR9 | PhosphoSitePlus; SysPTM |
| T164 | TSPTAtDSTSG | HPRD | |
| T155 | EKPAEtPVATS | HPRD; phosphoELM; SysPTM | |
| T159 | ETPVAtSPTAT | KAR9 | PhosphoSitePlus |
| T155 | EKPAEtPVATS | KAR9 | PhosphoSitePlus; SysPTM |
| S166 | PTATDsTSGDS | KAR9 | PhosphoSitePlus |
| Y359 | SGHMNyIQVTP | PhosphoSitePlus | |
| T162 | VATSPtATDST | HPRD; SysPTM | |
| Dephosphorylation site |
| RD23B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000350708 | D170N | COSMIC | Skin Cancer | 21984974 | ENSP00000350708 | T195I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000350708 | T195I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000350708 | Q293* | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000350708 | Breast Cancer | Metastasis | cell line | Up | 1.5 | 18582095 | ENSP00000350708 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.5 | 20543960 | ENSP00000350708 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.5 | 20543960 | ENSP00000350708 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.4 | 20543960 | ENSP00000350708 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Down | 0.06 | 17655343 | ENSP00000350708 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Down | 0.3 | 17655343 |
| Hyperphosphorylation site |
| RD23B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| STK38_HUMAN | RD23B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAPK5_HUMAN | RD23B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM1_HUMAN | RD23B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BTK_HUMAN | RD23B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK01_HUMAN | RD23B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | RD23B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | RD23B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | RD23B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A2_HUMAN | RD23B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RD23B_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0071942 | XPC complex | IDA | cellular_component |
| GO:0043161 | proteasomal ubiquitin-dependent protein catabolic | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006289 | nucleotide-excision repair | IEA | biological_process |
| GO:0006974 | response to DNA damage stimulus | IEA | biological_process |
| GO:0000718 | nucleotide-excision repair, DNA damage removal | TAS | biological_process |
| GO:0000502 | proteasome complex | IEA | cellular_component |
| GO:0003684 | damaged DNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0000715 | nucleotide-excision repair, DNA damage recognition | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0031593 | polyubiquitin binding | IDA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0032434 | regulation of proteasomal ubiquitin-dependent prot | IDA | biological_process |
| GO:0003697 | single-stranded DNA binding | TAS | molecular_function |
| GO:0007283 | spermatogenesis | IEA | biological_process |