Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RAC3_HUMAN
Description:ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [Source:HGNC Symbol;Acc:9803]
Location:chr17 q25.3
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y64AGQEDyDRLRPRasPhosphoSitePlus
T161ECSALtQRGLKRasPhosphoSitePlus
T167QRGLKtVFDEARasPhosphoSitePlus
S89LVSPAsFENVRRasPhosphoSitePlus
Y139LAPITyPQGLARasPhosphoSitePlus

Dephosphorylation site
RAC3_HUMAN do not have dephosphorylation site.

Mutation site
RAC3_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000304283Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
RAC3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAI2_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBG8_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBB2_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBG12_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBG13_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBG10_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBG2_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBG1_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBB3_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBB5_HUMANRAC3_HUMANGprotein -> effectorgpDB
GNAI3_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBG5_HUMANRAC3_HUMANGprotein -> effectorgpDB
GNAI1_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBG11_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBB1_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBG3_HUMANRAC3_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04370VEGF signaling pathway
hsa04310Wnt signaling pathway
hsa05210Colorectal cancer
hsa04662B cell receptor signaling pathway
hsa04360Axon guidance
hsa04520Adherens junction
hsa04650Natural killer cell mediated cytotoxicity
hsa05416Viral myocarditis
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05212Pancreatic cancer
hsa04510Focal adhesion
hsa04664Fc epsilon RI signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneTAScellular_component
GO:0030031cell projection assemblyIDAbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0012505endomembrane systemIDAcellular_component
GO:0016020membraneIEAcellular_component
GO:0015031protein transportIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0006184GTP catabolic processIDAbiological_process
GO:0050885neuromuscular process controlling balanceIEAbiological_process
GO:0031941filamentous actinIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005622intracellularIEAcellular_component
GO:0031175neuron projection developmentIEAbiological_process
GO:0030426growth coneIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0030036actin cytoskeleton organizationIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043005neuron projectionIDAcellular_component
GO:0035556intracellular signal transductionTASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0003924GTPase activityIDAmolecular_function
GO:0030027lamellipodiumIEAcellular_component
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0050905neuromuscular processIEAbiological_process
GO:0043025neuronal cell bodyIDAcellular_component


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