| UniProt/SwissProt ID: | PTN2_HUMAN |
| Description: | protein tyrosine phosphatase, non-receptor type 2 [Source:HGNC Symbol;Acc:9650] |
| Location: | chr18 p11.21 |
| Node attribute: | substrate; phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S304 | PAFDHsPNKIM | CDK1 | HPRD; SysPTM |
| S304 | PAFDHsPNKIM | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y22 | RWQPLyLEIRN | PhosphoSitePlus | |
| S298 | SKEDLsPAFDH | PhosphoSitePlus; HPRD; phosphoELM | |
| S304 | PAFDHsPNKIM | CDK2 | HPRD; SysPTM |
| Y32 | NESHDyPHRVA | PhosphoSitePlus | |
| S52 | RYRDVsPYDHS | Y_phosphatase | PhosphoSitePlus |
| S304 | PAFDHsPNKIM | CDK5 | HPRD; SysPTM |
| T340 | SKMQDtMEENS | IKKbetaNEMObind; YL1; Syn | PhosphoSitePlus |
| Y384 | RKRWLyWQPIL | Synaptobrevin | PhosphoSitePlus |
| Y54 | RDVSPyDHSRV | Y_phosphatase | PhosphoSitePlus |
| T261 | MGLIQtPDQLR | Y_phosphatase | PhosphoSitePlus |
| S293 | RWKELsKEDLS | PhosphoSitePlus | |
| S72 | DYINAsLVDIE | Y_phosphatase; CHASE3 | PhosphoSitePlus |
| T310 | PNKIMtEKYNG | PhosphoSitePlus | |
| Dephosphorylation site |
| PTN2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| PTN2_HUMAN do not have mutation site. |
| Differential expressed protein |
| PTN2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTN2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | PTN2_HUMAN | kinase -> substrate | HPRD |
| CDK2_HUMAN | PTN2_HUMAN | kinase -> substrate | HPRD |
| CDK5_HUMAN | PTN2_HUMAN | kinase -> substrate | HPRD |
| PTN2_HUMAN | STAT1_HUMAN | phosphatase -> substrate | HPRD |
| PTN2_HUMAN | SRC_HUMAN | phosphatase -> substrate | HPRD |
| PTN2_HUMAN | PGFRB_HUMAN | phosphatase -> substrate | HPRD |
| PTN2_HUMAN | JAK1_HUMAN | phosphatase -> substrate | HPRD |
| PTN2_HUMAN | INSR_HUMAN | phosphatase -> substrate | HPRD |
| PTN2_HUMAN | SHC1_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| PTN2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IDA | cellular_component |
| GO:0006470 | protein dephosphorylation | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0006470 | protein dephosphorylation | IEA | biological_process |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0060334 | regulation of interferon-gamma-mediated signaling | TAS | biological_process |
| GO:0004726 | non-membrane spanning protein tyrosine phosphatase | IEA | molecular_function |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | TAS | biological_process |
| GO:0016311 | dephosphorylation | IEA | biological_process |
| GO:0008286 | insulin receptor signaling pathway | IEA | biological_process |
| GO:0060333 | interferon-gamma-mediated signaling pathway | TAS | biological_process |