Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PP1A_HUMAN
Description:protein phosphatase 1, catalytic subunit, alpha isozyme [Source:HGNC Symbol;Acc:9281]
Location:chr11 q13.2
Node attribute:phosphotase; substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S325TPPRNsAKAKKPhosphoSitePlus
Y134SINRIyGFYDEMetallophosPhosphoSitePlus
T320GGRPItPPRNSCDK_groupphosphoELM; RegPhos; SysPTM
S129NHECAsINRIYMetallophosPhosphoSitePlus
Y137RIYGFyDECKRMetallophosPhosphoSitePlus
S11KLNLDsIIGRLPhosphoSitePlus; HPRD
Y255VVEDGyEFFAKPhosphoSitePlus
T320GGRPItPPRNSCDC2(CDK1RegPhos; SysPTM
T320GGRPItPPRNSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T320GGRPItPPRNSCDK2RegPhos; SysPTM
T320GGRPItPPRNSCDK1phosphoELM; SysPTM
T331GGRPItPPRNSHPRD
S22LEVQGsRPGKNPhosphoSitePlus; HPRD
Y306KNKGKyGQFSGPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T320NPGGRPItPPRNSAKHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365936G80SCOSMICBreast Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000365936Breast CancerTreatment (Antiestrogen-sensitive vs. Antiestrogen-resistant)cell lineDown0.4314557597
ENSP00000365936Breast CancerNormal vs. CancertissueUp0.4520739354
ENSP00000365936Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.2415169874

Hyperphosphorylation site
PP1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK2_HUMANPP1A_HUMANkinase -> substrateRegPhos
CDK1_HUMANPP1A_HUMANkinase -> substrateRegPhos
PP1A_HUMANAXIN1_HUMANphosphatase -> substrateHPRD
PP1A_HUMANCALL6_HUMANphosphatase -> substrateKEGG
PP1A_HUMANKPCD_HUMANphosphatase -> substrateHPRD
PP1A_HUMANGYS1_HUMANphosphatase -> substrateKEGG
PP1A_HUMANPYR1_HUMANphosphatase -> substrateHPRD
PP1A_HUMANH2AX_HUMANphosphatase -> substrateHPRD
AKT3_HUMANPP1A_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa04114Oocyte meiosis
hsa05034Alcoholism
hsa04270Vascular smooth muscle contraction
hsa03015mRNA surveillance pathway
hsa04510Focal adhesion
hsa04720Long-term potentiation
hsa04910Insulin signaling pathway
hsa05031Amphetamine addiction
hsa04728Dopaminergic synapse
hsa05168Herpes simplex infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043005neuron projectionIEAcellular_component
GO:0043021ribonucleoprotein complex bindingIEAmolecular_function
GO:0070688MLL5-L complexIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005730nucleolusIEAcellular_component
GO:0043197dendritic spineIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0006470protein dephosphorylationIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0004722protein serine/threonine phosphatase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0007049cell cycleIEAbiological_process
GO:0005981regulation of glycogen catabolic processIEAbiological_process
GO:0019433triglyceride catabolic processTASbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0005977glycogen metabolic processIEAbiological_process
GO:0000164protein phosphatase type 1 complexIEAcellular_component
GO:0042587glycogen granuleIEAcellular_component
GO:0004721phosphoprotein phosphatase activityIEAmolecular_function
GO:0016787hydrolase activityIEAmolecular_function
GO:0006629lipid metabolic processTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005979regulation of glycogen biosynthetic processIEAbiological_process
GO:0005654nucleoplasmIEAcellular_component
GO:0043204perikaryonIEAcellular_component
GO:0072357PTW/PP1 phosphatase complexIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0005515protein bindingIPImolecular_function


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