| UniProt/SwissProt ID: | PE2R3_HUMAN |
| Description: | prostaglandin E receptor 3 (subtype EP3) [Source:HGNC Symbol;Acc:9595] |
| Location: | chr1 p31.1 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T107 | GQLLTtPVVIV | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| PE2R3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| PE2R3_HUMAN do not have mutation site. |
| Differential expressed protein |
| PE2R3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PE2R3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PE2R3_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| PE2R3_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| PE2R3_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| PE2R3_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| PE2R3_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| PE2R3_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| PE2R3_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| PE2R3_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04020 | Calcium signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006351 | transcription, DNA-dependent | TAS | biological_process |
| GO:0004957 | prostaglandin E receptor activity | NAS | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0005635 | nuclear envelope | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0004879 | ligand-activated sequence-specific DNA binding RNA | TAS | molecular_function |
| GO:0008219 | cell death | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0030522 | intracellular receptor mediated signaling pathway | TAS | biological_process |
| GO:0031622 | positive regulation of fever generation | ISS | biological_process |