Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PAXI_HUMAN
Description:paxillin [Source:HGNC Symbol;Acc:9718]
Location:chr12 q24.31
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y118EEEHVySFPNKphosphoELM; RegPhos; SysPTM
Y88SSSPVyGSSAKphosphoELM; RegPhos; SysPTM
S260TRISAsSATREPhosphoSitePlus
S250PQRVTsTQQQTPaxillinPhosphoSitePlus
S230ESSVPsPVPAIHPRD
S188VPETNsPLGGKHPRD; RegPhos
S178LPGALsPLYGVJNK1RegPhos
S84QQPQSsSPVYGPaxillinPhosphoSitePlus
Y31SEETPySYPTGPhosphoSitePlus; phosphoELM; RegPhos
S380YHNLFsPRCYYHPRD
Y88SSSPVyGSSAKCSKHPRD; RegPhos; SysPTM
S83HQQPQsSSPVYHPRD
Y31SEETPySYPTGFAKphosphoELM; RegPhos
S126PNKQKsAEPSPPaxillinPhosphoSitePlus
S95SSAKTsSVSNPPaxillinPhosphoSitePlus
T136PTVMStSLGSNHPRD; phosphoELM
T39PTGNHtYQEIAPhosphoSitePlus
Y88SSSPVyGSSAKPaxillinPhosphoSitePlus; SysPTM
Y118EEEHVySFPNKPaxillinPhosphoSitePlus; SysPTM
Y31SEETPySYPTGBrkphosphoELM; RegPhos
T29FLSEEtPYSYPPhosphoSitePlus
S219RPSVEsLLDELHPRD
S303DGGRSsPGGQDPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
Y88SSSPVyGSSAKSRCphosphoELM; SysPTM
S85QPQSSsPVYGSPaxillinPhosphoSitePlus; SysPTM
Y88SSSPVyGSSAKSrcRegPhos; SysPTM
Y181ALSPLyGVPETPaxillinPhosphoSitePlus
T236PVPAItVNQGEHPRD
Y118EEEHVySFPNKSrcRegPhos; SysPTM
S332PPKPGsQLDSMphosphoELM
S287GKTGSsSPPGGHPRD
S106QDSVGsPCSRVPaxillinPhosphoSitePlus
Y40TGNHTyQEIAVCSKHPRD; RegPhos
S178LPGALsPLYGVMAPK8HPRD
S298PPKPGsQLDSMHPRD
Y40TGNHTyQEIAVPhosphoSitePlus; phosphoELM
Y40TGNHTyQEIAVSRCphosphoELM
S109VGSPCsRVGEEPaxillinPhosphoSitePlus
T249SPQRVtSTQQQPaxillinPhosphoSitePlus
Y40TGNHTyQEIAVSrcRegPhos
S169ADEANsSPPLPHPRD
S130KSAEPsPTVMSPaxillinPhosphoSitePlus
S258QQTRIsASSATPhosphoSitePlus; HPRD
T132AEPSPtVMSTSHPRD; phosphoELM
S32EETPYsYPTGNPhosphoSitePlus
S322KTGSSsPPGGPphosphoELM
S119EEHVYsFPNKQPaxillinPhosphoSitePlus
S244QGEMSsPQRVTHPRD
Y118EEEHVySFPNKFAKphosphoELM; RegPhos; SysPTM
Y117GEEEHvYSFPNHPRD
T255STQQQtRISASPhosphoSitePlus
S84QQPQSsSPVYGHPRD
S170DEANSsPPLPGHPRD
S109VGSPCsRVGEERegPhos
S243NQGEMsSPQRVPaxillinPhosphoSitePlus
Y33ETPYSyPTGNHPhosphoSitePlus
Y31SEETPySYPTGSrcRegPhos
S302RDGGRsSPGGQPhosphoSitePlus; phosphoELM
T284MAQGKtGSSSPHPRD
S90SPVYGsSAKTSPaxillinPhosphoSitePlus
S85QPQSSsPVYGSHPRD; phosphoELM; SysPTM
S261RISASsATRELPhosphoSitePlus; HPRD; phosphoELM
S135SPTVMsTSLGSHPRD
T35PYSYPtGNHTYPhosphoSitePlus
S126PNKQKsAEPSPHPRD; phosphoELM; RegPhos
T251QRVTStQQQTRPaxillinPhosphoSitePlus
Y181ALSPLyGVPETHPRD; phosphoELM; RegPhos
T318MAQGKtGSSSPphosphoELM
S288KTGSSsPPGGPHPRD
S106QDSVGsPCSRVHPRD; phosphoELM; RegPhos
Y118EEEHVySFPNKBrkphosphoELM; RegPhos; SysPTM
S130KSAEPsPTVMSHPRD; phosphoELM; RegPhos
Y87QSSSPvYGSSAHPRD
S83HQQPQsSSPVYPaxillinPhosphoSitePlus
Y118EEEHVySFPNKPTK2HPRD; SysPTM
S178LPGALsPLYGVPaxillinPhosphoSitePlus
T186YGVPEtNSPLGHPRD
T263SASSAtRELDEPhosphoSitePlus
S119EEHVYsFPNKQHPRD; phosphoELM
S137TVMSTsLGSNLPaxillinPhosphoSitePlus
S137TVMSTsLGSNLHPRD; phosphoELM
S321GKTGSsSPPGGphosphoELM
S103SNPQDsVGSPCHPRD
S244QGEMSsPQRVTPaxillinPhosphoSitePlus
S103SNPQDsVGSPCPaxillinPhosphoSitePlus
Y31SEETPySYPTGPTK2HPRD

Dephosphorylation site
PAXI_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000391283E241DCOSMICOvarian Cancer21720365
ENSP00000391283S502YCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000391283Lung CancerNormal vs. CancertissueUp15626334

Hyperphosphorylation site
PAXI_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK_HUMANPAXI_HUMANkinase -> substrateRegPhos
MK08_HUMANPAXI_HUMANkinase -> substrateHPRD; RegPhos
PTK6_HUMANPAXI_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANPAXI_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANPAXI_HUMANkinase -> substrateRegPhos
VGFR2_HUMANPAXI_HUMANotherKEGG
PAXI_HUMANACTG_HUMANotherKEGG
CRK_HUMANPAXI_HUMANotherKEGG
GIT1_HUMANPAXI_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa04370VEGF signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa04062Chemokine signaling pathway
hsa04510Focal adhesion
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0005925focal adhesionIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0000187activation of MAPK activityIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005875microtubule associated complexTAScellular_component
GO:0048041focal adhesion assemblyIEAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0006936muscle contractionTASbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0006928cellular component movementIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0031252cell leading edgeIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0060396growth hormone receptor signaling pathwayIDAbiological_process
GO:0005938cell cortexIEAcellular_component
GO:0030032lamellipodium assemblyIEAbiological_process
GO:0034614cellular response to reactive oxygen speciesIEPbiological_process
GO:0034329cell junction assemblyTASbiological_process
GO:0007155cell adhesionNASbiological_process
GO:0017166vinculin bindingIPImolecular_function
GO:0005178integrin bindingIEAmolecular_function
GO:0007010cytoskeleton organizationIEAbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007172signal complex assemblyTASbiological_process
GO:0008013beta-catenin bindingIPImolecular_function
GO:0030027lamellipodiumIEAcellular_component
GO:0051435BH4 domain bindingIEAmolecular_function