Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GIT1_HUMAN
Description:G protein-coupled receptor kinase interacting ArfGAP 1 [Source:HGNC Symbol;Acc:4272]
Location:chr17 q11.2
Node attribute:PPI(target); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S362GKSLSsPTDNLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T500ERAEHtPMAPGHPRD
T480PGPVPtPPLPSDUF972; DUF904PhosphoSitePlus
Y545EDDAIySVHVPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S605GSGADsDYENTHPRD
S601LSRHGsGADSDHPRD
S570VPFTPsSPLLSPhosphoSitePlus; SysPTM
Y554EDDAIySVHVPHPRD
Y519QAFSMyEPGSAHPRD
S630HPELEsLDGDLHPRD
T537QPFHStELEDDPhosphoSitePlus; HPRD
T610SDYENtQSGDPHPRD
S585GSRHTsKLSRHPhosphoSitePlus
T480PGPVPtPPLPSHPRD
T401ASDEDtDQEPLHPRD
S417DSSDLsDGAVTHPRD; phosphoELM
S577PLLSCsQEGSRPhosphoSitePlus
Y563VPAGLyRIRKGHPRD
Y598GADSDyENTQSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T499APGGStHRRDRHPRD
S426DSSDLsDGAVTHPRD
S596GSGADsDYENTPhosphoSitePlus; HPRD; phosphoELM
T753AKQLVtITTREGIT1_CPhosphoSitePlus
T373SLSSPtDNLELHPRD
T491ERAEHtPMAPGDUF972; DUF904PhosphoSitePlus
S508DRQAFsMYEPGPhosphoSitePlus; phosphoELM
S546DDAIYsVHVPAPhosphoSitePlus; HPRD
S388YDSVAsDEDTDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S359RQQGKsLSSPTHPRD; SysPTM
T392ASDEDtDQEPLPhosphoSitePlus; HPRD; phosphoELM
S385QHDYDsVASDEPhosphoSitePlus; HPRD; phosphoELM
S370DNLELsLRSQSPhosphoSitePlus
Y284LAMDVyDEVDRHPRD
S571PFTPSsPLLSCPhosphoSitePlus; SysPTM
S375SLRSQsDLDDQPhosphoSitePlus; HPRD
S397YDSVAsDEDTDHPRD
S370QGKSLsSPTDNHPRD
S46LGRHIsIVKHLArfGapPhosphoSitePlus
S422ARSMDsSDLSDHPRD
T169PEKGTtPLHVAAnk_2PhosphoSitePlus
S597HTSKLsRHGSGHPRD
T364SLSSPtDNLELPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S588HTSKLsRHGSGHPRD
S419SNRARsMDSSDHPRD
S563KGVSAsAVPFTHPRD
Y554VPAGLyRIRKGPhosphoSitePlus; HPRD; phosphoELM
S561IRKGVsASAVPPhosphoSitePlus
Y383DDQHDyDSVASPhosphoSitePlus; HPRD; phosphoELM
Y510QAFSMyEPGSAPhosphoSitePlus; HPRD
T601SDYENtQSGDPPhosphoSitePlus; HPRD
Y321PVNPEySATRNPhosphoSitePlus
S700LEPVRsSLRLLGIT1_CPhosphoSitePlus
T568SAVPFtPSSPLPhosphoSitePlus
T508APGGStHRRDRHPRD
T491ERAEHtPMAPGHPRD
S555DDAIYsVHVPAHPRD
S413ARSMDsSDLSDHPRD; phosphoELM
S410SNRARsMDSSDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S384SLRSQsDLDDQHPRD
Y284LAMDVyDEVDRDUF4319; GIT_SHDPhosphoSitePlus
S536LQPFHsTELEDPhosphoSitePlus; HPRD
S592LSRHGsGADSDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T168HPEKGtTPLHVAnk_2PhosphoSitePlus
Y246HKNGHyIIPQMHPRD
S134TAKDLsKQLHSHPRD; phosphoELM; SysPTM
S382ELSLRsQSDLDHPRD
S394QHDYDsVASDEHPRD
Y607GADSDyENTQSHPRD
S368RQQGKsLSSPTHPRD
S373ELSLRsQSDLDPhosphoSitePlus; HPRD; phosphoELM
S417DSSDLsDGAVTDUF972PhosphoSitePlus
S514MYEPGsALKPFPhosphoSitePlus
Y224LVECQyELTDRAnk_2PhosphoSitePlus
S371GKSLSsPTDNLHPRD
S414RSMDSsDLSDGHPRD; phosphoELM
Y392DDQHDyDSVASHPRD
S423RSMDSsDLSDGHPRD
S361QGKSLsSPTDNPhosphoSitePlus; HPRD
Y111FIRAKyQMLAFArfGapPhosphoSitePlus

Dephosphorylation site
GIT1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000225394R409QCOSMICHead and Neck Cancer21798893

Differential expressed protein
GIT1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GIT1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PTPRZ_HUMANGIT1_HUMANkinase -> substrateKEGG
ARHG7_HUMANGIT1_HUMANotherKEGG
GIT1_HUMANPAXI_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04810Regulation of actin cytoskeleton
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0008277regulation of G-protein coupled receptor protein sTASbiological_process
GO:0008060ARF GTPase activator activityIEAmolecular_function
GO:0032312regulation of ARF GTPase activityIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005925focal adhesionIDAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component


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