Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZEB1_HUMAN
Description:zinc finger E-box binding homeobox 1 [Source:HGNC Symbol;Acc:11642]
Location:chr10 p11.22
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S645QSSEPsSPEPGHPRD
S995AEERDsTEQEEPhosphoSitePlus
S701NGSRSsTPSPSPhosphoSitePlus; HPRD; phosphoELM
T243RKFKCtECGKAzf-C2H2PhosphoSitePlus
T716SSSRNtQGYLYPhosphoSitePlus
S319PSLSAsPGSPTPhosphoSitePlus; HPRD; phosphoELM
S322SASPGsPTRPQPhosphoSitePlus; HPRD; phosphoELM
S641QISVQsSEPSSPhosphoSitePlus
S313TSQCSsPSLSAPhosphoSitePlus; HPRD; phosphoELM
S704RSSTPsPSPLNPhosphoSitePlus; HPRD; phosphoELM
S312KTSQCsSPSLSHPRD; phosphoELM
S31VVETNsDSDDEPhosphoSitePlus; HPRD; phosphoELM
S889QNDSDsTPPKKPhosphoSitePlus
S285SGSYSsHISSKzf-C2H2PhosphoSitePlus
S642ISVQSsEPSSPPhosphoSitePlus; HPRD
T996EERDStEQEEAPhosphoSitePlus
S1100DDRAEsQASSLPhosphoSitePlus
S646SSEPSsPEPGKPhosphoSitePlus; HPRD; phosphoELM
S263HLRIHsGEKPYPhosphoSitePlus
S887EDQNDsDSTPPPhosphoSitePlus
S155GTPEAsGHDENPhosphoSitePlus
S282FSHSGsYSSHIzf-C2H2PhosphoSitePlus
S583GDGNLsPSQPPHPRD
S698STTNGsRSSTPphosphoELM
S317SSPSLsASPGSPhosphoSitePlus; HPRD; phosphoELM
S679TVNLQsPLKMTPhosphoSitePlus; HPRD; phosphoELM
S700TNGSRsSTPSPPhosphoSitePlus; HPRD
T890NDSDStPPKKKPhosphoSitePlus
S693VLPVGsTTNGSHPRD; phosphoELM
S315QCSSPsLSASPPhosphoSitePlus; HPRD; phosphoELM
T162HDENGtPDAFSPhosphoSitePlus
S706STPSPsPLNLSHPRD; phosphoELM
S673NEPQDsTVNLQHPRD
S309TGLKTsQCSSPPhosphoSitePlus
S33ETNSDsDDEDKPhosphoSitePlus; HPRD; phosphoELM
T702GSRSStPSPSPPhosphoSitePlus; HPRD; phosphoELM
T324SPGSPtRPQIRPhosphoSitePlus
S521SEKDKsFEGGVPhosphoSitePlus

Dephosphorylation site
ZEB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000319248P404SCOSMICSkin Cancer21984974
ENSP00000319248E244QBIOMARTBreast Cancer21930507, 21930502
ENSP00000319248E925QCOSMICHead and Neck Cancer21798893
ENSP00000319248D115ECOSMICOvarian Cancer21720365
ENSP00000319248E128KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000319248S638LCOSMICCentral Nervous System Neoplasms18772396
ENSP00000319248H222LCOSMICHead and Neck Cancer21798893
ENSP00000319248L259FBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000319248T308ICOSMICOvarian Cancer21720365
ENSP00000319248E1074KCOSMICHead and Neck Cancer21798893
ENSP00000319248L681FCOSMICSkin Cancer21984974

Differential expressed protein
ZEB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ZEB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZEB1_HUMANP73_HUMANTF -> target geneTRANSFAC
ZEB1_HUMANIL2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ZEB1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051150regulation of smooth muscle cell differentiationIEAbiological_process
GO:0051216cartilage developmentIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0048598embryonic morphogenesisIEAbiological_process
GO:0048513organ developmentIEAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006955immune responseTASbiological_process
GO:0030857negative regulation of epithelial cell differentiaIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0003713transcription coactivator activityTASmolecular_function
GO:0008134transcription factor bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0048704embryonic skeletal system morphogenesisIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0007417central nervous system developmentIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0017015regulation of transforming growth factor beta receIEAbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0070888E-box bindingIEAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0048596embryonic camera-type eye morphogenesisIEAbiological_process
GO:0071560cellular response to transforming growth factor beIEAbiological_process
GO:0033081regulation of T cell differentiation in thymusIEAbiological_process
GO:0010464regulation of mesenchymal cell proliferationIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0031667response to nutrient levelsIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0071230cellular response to amino acid stimulusIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0014823response to activityIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0003714transcription corepressor activityTASmolecular_function