Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NODAL_HUMAN
Description:nodal growth differentiation factor [Source:HGNC Symbol;Acc:7865]
Location:chr10 q22.1
Node attribute:PPI(source); ligand; PPI(target)

Phosphorylation site
NODAL_HUMAN do not have phosphorylation site.

Dephosphorylation site
NODAL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000287139D120NCOSMICRenal Cancer20054297
ENSP00000287139E279KSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000287139E279KHPIColorectal Cancer16959974
ENSP00000287139F79LCOSMICHead and Neck Cancer21798893

Differential expressed protein
NODAL_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NODAL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NODAL_HUMANAVR2A_HUMANligand -> receptorHPMR
NODAL_HUMANAVR2B_HUMANligand -> receptorHPMR
NODAL_HUMANACV1C_HUMANligand -> receptorHPMR
NODAL_HUMANACV1B_HUMANligand -> receptorHPMR
NODAL_HUMANAVR2A_HUMANotherKEGG
LFTY1_HUMANNODAL_HUMANotherKEGG
INHBA_HUMANNODAL_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04350TGF-beta signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007492endoderm developmentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0001842neural fold formationIEAbiological_process
GO:0048018receptor agonist activityIEAmolecular_function
GO:0009880embryonic pattern specificationIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:1900224positive regulation of nodal signaling pathway invISSbiological_process
GO:1901383negative regulation of chorionic trophoblast cell IDAbiological_process
GO:0038092nodal signaling pathwayIEAbiological_process
GO:0022409positive regulation of cell-cell adhesionIMPbiological_process
GO:0019827stem cell maintenanceIEAbiological_process
GO:0060136embryonic process involved in female pregnancyIEAbiological_process
GO:0001892embryonic placenta developmentIEAbiological_process
GO:1901164negative regulation of trophoblast cell migrationIDAbiological_process
GO:0060766negative regulation of androgen receptor signalingIDAbiological_process
GO:0010085polarity specification of proximal/distal axisIEAbiological_process
GO:0001707mesoderm formationIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0060460left lung morphogenesisIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0048546digestive tract morphogenesisIEAbiological_process
GO:0009948anterior/posterior axis specificationIEAbiological_process
GO:0090010transforming growth factor beta receptor signalingIEAbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0007420brain developmentIEAbiological_process
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0010575positive regulation vascular endothelial growth faIMPbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIDAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0048701embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0045766positive regulation of angiogenesisIMPbiological_process
GO:0048382mesendoderm developmentIMPbiological_process
GO:0001890placenta developmentIMPbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0001702gastrulation with mouth forming secondIEAbiological_process
GO:0007369gastrulationIEAbiological_process
GO:0090009primitive streak formationIEAbiological_process
GO:0035050embryonic heart tube developmentIEAbiological_process
GO:0048327axial mesodermal cell fate specificationIEAbiological_process
GO:0007368determination of left/right symmetryIEAbiological_process
GO:0043280positive regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIMPbiological_process
GO:0048859formation of anatomical boundaryIEAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0002085inhibition of neuroepithelial cell differentiationIEAbiological_process
GO:0010470regulation of gastrulationIEAbiological_process
GO:0010862positive regulation of pathway-restricted SMAD proIMPbiological_process
GO:0040007growthIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0016015morphogen activityNASmolecular_function
GO:0033505floor plate morphogenesisIEAbiological_process
GO:0032927positive regulation of activin receptor signaling IGIbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0060395SMAD protein signal transductionIEAbiological_process
GO:0035987endodermal cell differentiationIMPbiological_process
GO:0070698type I activin receptor bindingIMPmolecular_function
GO:0055123digestive system developmentIEAbiological_process
GO:0001944vasculature developmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0009966regulation of signal transductionIEAbiological_process
GO:0048382mesendoderm developmentIEAbiological_process
GO:0060802epiblast cell-extraembryonic ectoderm cell signaliIEAbiological_process
GO:1900164nodal signaling pathway involved in determination IEAbiological_process
GO:0048729tissue morphogenesisIEAbiological_process
GO:0042074cell migration involved in gastrulationIEAbiological_process
GO:2000036regulation of stem cell maintenanceTASbiological_process
GO:0001829trophectodermal cell differentiationIEAbiological_process
GO:0060391positive regulation of SMAD protein import into nuIMPbiological_process
GO:0048646anatomical structure formation involved in morphogIEAbiological_process
GO:0001831trophectodermal cellular morphogenesisIEAbiological_process