Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MPIP1_HUMAN
Description:cell division cycle 25A [Source:HGNC Symbol;Acc:1725]
Location:chr3 p21.31
Node attribute:phosphotase; substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S124LKRSHsDSLDHCHK2phosphoELM; RegPhos
S124LKRSHsDSLDHCHK1phosphoELM; RegPhos
S293TKRRKsMSGASCHK1phosphoELM; RegPhos
S295RRKSMsGASPKM-inducer_phospPhosphoSitePlus
S82SESTDsGFCLDPhosphoSitePlus; phosphoELM; RegPhos
S76LQRMGsSESTDCHK1phosphoELM; RegPhos
S293TKRRKsMSGASM-inducer_phospPhosphoSitePlus
S116KLLGCsPALKRPIM1HPRD; RegPhos
S116KLLGCsPALKRM-inducer_phospPhosphoSitePlus
S124LKRSHsDSLDHHPRD
S178TQRQNsAPARMCHEK1HPRD
S178TQRQNsAPARMCHEK2HPRD
S77QRMGSsESTDSPhosphoSitePlus
S519KREMYsRLKKLPhosphoSitePlus
S279KRPERsQEESPCHEK2HPRD
T507RTKSRtWAGEKPhosphoSitePlus
S239PSCMAsLWTAPCHK2RegPhos
S239PSCMAsLWTAPCHK1RegPhos
S76LQRMGsSESTDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S116KLLGCsPALKRPIM-1phosphoELM
S116KLLGCsPALKRCDC2(CDK1RegPhos
S513WAGEKsKREMYPhosphoSitePlus
S116KLLGCsPALKRCDK1HPRD; phosphoELM
S293TKRRKsMSGASCHEK1HPRD
S293TKRRKsMSGASCHEK2HPRD
S18LLFACsPPPASPhosphoSitePlus
S124LKRSHsDSLDHM-inducer_phospPhosphoSitePlus
S116KLLGCsPALKRCDC2RegPhos
S253TKRRKsMSGASCHEK1HPRD
S253TKRRKsMSGASCHEK2HPRD
S279KRPERsQEESPCHEK1HPRD
S178TQRQNsAPARMCHK2phosphoELM; RegPhos
S178TQRQNsAPARMCHK1phosphoELM; RegPhos
S124LKRSHsDSLDHCHEK1HPRD
S79MGSSEsTDSGFPhosphoSitePlus; phosphoELM; RegPhos
S88GFCLDsPGPLDM-inducer_phospPhosphoSitePlus
T507RTKSRtWAGEKCHK1phosphoELM; RegPhos
S18LLFACsPPPASCDK1HPRD; phosphoELM
S279KRPERsQEESPM-inducer_phospPhosphoSitePlus
S321LSLASsPKGTIM-inducer_phospPhosphoSitePlus
S88GFCLDsPGPLDphosphoELM; RegPhos
S126RSHSDsLDHDIM-inducer_phospPhosphoSitePlus
S178TQRQNsAPARMM-inducer_phospPhosphoSitePlus
T80GSSEStDSGFCPhosphoSitePlus
S18LLFACsPPPASCDC2(CDK1RegPhos
S279KRPERsQEESPCHK2phosphoELM; RegPhos
S279KRPERsQEESPCHK1phosphoELM; RegPhos
S293TKRRKsMSGASCHK2phosphoELM; RegPhos
S18LLFACsPPPASCDC2RegPhos
S239KRPERsQEESPCHEK2HPRD
S239KRPERsQEESPCHEK1HPRD

Dephosphorylation site
MPIP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000303706E147KCOSMICLung Cancer20668451
ENSP00000303706R506QDing2008, COSMICLung Cancer18948947
ENSP00000303706F218ICOSMICRenal Cancer20054297
ENSP00000303706G37WDing2008, COSMICLung Cancer18948947

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000303706Uterine CancerNormal vs. Cancercell lineUp2.215838902

Hyperphosphorylation site
MPIP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CHK2_HUMANMPIP1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PIM1_HUMANMPIP1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CHK1_HUMANMPIP1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMPIP1_HUMANkinase -> substrateRegPhos
CDK1_HUMANMPIP1_HUMANkinase -> substrateRegPhos
TGFR2_HUMANMPIP1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMPIP1_HUMANkinase -> substrateRobert H Newman (2013)
MPIP1_HUMANCDK2_HUMANphosphatase -> substrateKEGG
MPIP1_HUMANCDK1_HUMANphosphatase -> substrateKEGG
MPIP1_HUMANRAF1_HUMANphosphatase -> substrateHPRD
MPIP1_HUMANCDK4_HUMANphosphatase -> substrateKEGG
E2F1_HUMANMPIP1_HUMANTF -> target geneTRANSFAC
MYC_HUMANMPIP1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04914Progesterone-mediated oocyte maturation
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0006470protein dephosphorylationIEAbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0009314response to radiationIDAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0034644cellular response to UVIDAbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0006260DNA replicationTASbiological_process
GO:0007067mitosisIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0008283cell proliferationTASbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0000087M phase of mitotic cell cycleIEAbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function


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