Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M4K5_HUMAN
Description:mitogen-activated protein kinase kinase kinase kinase 5 [Source:HGNC Symbol;Acc:6867]
Location:chr14 q22.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S335AERTAsEINFDPhosphoSitePlus; HPRD; phosphoELM
Y35TYGDVyKARNVPkinasePhosphoSitePlus
Y303DNHAHyTEADDPhosphoSitePlus
S400KPRISsYPEDNPhosphoSitePlus
Y401PRISSyPEDNFPhosphoSitePlus
S436RQSSPsCGPVAPhosphoSitePlus
S445VAETSsIGNGDPhosphoSitePlus
S845AGHENHPRD
Y20NPQQDyELVQRPkinasePhosphoSitePlus
Y558KCTWLyVINNTCNHPhosphoSitePlus
T30RVGSGtYGDVYPkinasePhosphoSitePlus
S174IAKRKsFIGTPPkinasePhosphoSitePlus
S434LRRQSsPSCGPPhosphoSitePlus
T304NHAHYtEADDDPhosphoSitePlus
T178KSFIGtPYWMAPkinasePhosphoSitePlus
T267PKKRPtAERLLPkinasePhosphoSitePlus
Y31VGSGTyGDVYKPkinasePhosphoSitePlus
S816FRLLGsDRVVVHPRD
T320AIIRHtIRSTNPhosphoSitePlus
S433ILRRQsSPSCGPhosphoSitePlus
S399PKPRIsSYPEDPhosphoSitePlus
Y31VGSGTyGDVYKHPRD; phosphoELM

Dephosphorylation site
M4K5_HUMAN do not have dephosphorylation site.

Mutation site
M4K5_HUMAN do not have mutation site.

Differential expressed protein
M4K5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M4K5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K14_HUMANM4K5_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANM4K5_HUMANkinase -> substrateRobert H Newman (2013)
M4K5_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANM4K5_HUMANkinase -> substrateRobert H Newman (2013)
M4K5_HUMANMED28_HUMANkinase -> substrateRobert H Newman (2013)
M4K5_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
M4K5_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANM4K5_HUMANkinase -> substrateRobert H Newman (2013)
M4K5_HUMANGLYAT_HUMANkinase -> substrateRobert H Newman (2013)
M4K5_HUMANNAR4_HUMANkinase -> substrateRobert H Newman (2013)
M4K5_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
MYLK2_HUMANM4K5_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
M4K5_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006950response to stressIDAbiological_process
GO:0005083small GTPase regulator activityIEAmolecular_function
GO:0007257activation of JUN kinase activityTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function


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