| UniProt/SwissProt ID: | M4K5_HUMAN |
| Description: | mitogen-activated protein kinase kinase kinase kinase 5 [Source:HGNC Symbol;Acc:6867] |
| Location: | chr14 q22.1 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S335 | AERTAsEINFD | PhosphoSitePlus; HPRD; phosphoELM | |
| Y35 | TYGDVyKARNV | Pkinase | PhosphoSitePlus |
| Y303 | DNHAHyTEADD | PhosphoSitePlus | |
| S400 | KPRISsYPEDN | PhosphoSitePlus | |
| Y401 | PRISSyPEDNF | PhosphoSitePlus | |
| S436 | RQSSPsCGPVA | PhosphoSitePlus | |
| S445 | VAETSsIGNGD | PhosphoSitePlus | |
| S845 | AGHEN | HPRD | |
| Y20 | NPQQDyELVQR | Pkinase | PhosphoSitePlus |
| Y558 | KCTWLyVINNT | CNH | PhosphoSitePlus |
| T30 | RVGSGtYGDVY | Pkinase | PhosphoSitePlus |
| S174 | IAKRKsFIGTP | Pkinase | PhosphoSitePlus |
| S434 | LRRQSsPSCGP | PhosphoSitePlus | |
| T304 | NHAHYtEADDD | PhosphoSitePlus | |
| T178 | KSFIGtPYWMA | Pkinase | PhosphoSitePlus |
| T267 | PKKRPtAERLL | Pkinase | PhosphoSitePlus |
| Y31 | VGSGTyGDVYK | Pkinase | PhosphoSitePlus |
| S816 | FRLLGsDRVVV | HPRD | |
| T320 | AIIRHtIRSTN | PhosphoSitePlus | |
| S433 | ILRRQsSPSCG | PhosphoSitePlus | |
| S399 | PKPRIsSYPED | PhosphoSitePlus | |
| Y31 | VGSGTyGDVYK | HPRD; phosphoELM | |
| Dephosphorylation site |
| M4K5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| M4K5_HUMAN do not have mutation site. |
| Differential expressed protein |
| M4K5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| M4K5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| M3K14_HUMAN | M4K5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR4_HUMAN | M4K5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M4K5_HUMAN | SRC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | M4K5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M4K5_HUMAN | MED28_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M4K5_HUMAN | CHIP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M4K5_HUMAN | KAP0_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| JAK2_HUMAN | M4K5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M4K5_HUMAN | GLYAT_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M4K5_HUMAN | NAR4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M4K5_HUMAN | SRXN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MYLK2_HUMAN | M4K5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| M4K5_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006950 | response to stress | IDA | biological_process |
| GO:0005083 | small GTPase regulator activity | IEA | molecular_function |
| GO:0007257 | activation of JUN kinase activity | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0007243 | intracellular protein kinase cascade | IDA | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |