Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M4K1_HUMAN
Description:mitogen-activated protein kinase kinase kinase kinase 1 [Source:HGNC Symbol;Acc:6863]
Location:chr19 q13.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S374PRKQLsESSDDPhosphoSitePlus; phosphoELM; RegPhos
S376KQLSEsSDDDYPhosphoSitePlus; phosphoELM; RegPhos
S586PIAHIsPHRLLCNHPhosphoSitePlus
S325STHRSsSLGIPPhosphoSitePlus
S421DDGQLsPGVLVMAP4K1HPRD
Y381SSDDDyDDVDIPhosphoSitePlus; phosphoELM; RegPhos
S413DEGPGsMGDDGPhosphoSitePlus; phosphoELM; RegPhos
S447PPSTSsPHLTAPhosphoSitePlus
S171LARRLsFIGTPPkinasePhosphoSitePlus
S320PRRIRsTHRSSPhosphoSitePlus
Y381SSDDDyDDVDILYNRegPhos
S430LVRCAsGPPPNPhosphoSitePlus
S405KPKFRsPSDEGPhosphoSitePlus
Y381SSDDDyDDVDISYKphosphoELM; RegPhos
S454HLTAHsEPSLWPhosphoSitePlus
S421DDGQLsPGVLVPhosphoSitePlus; phosphoELM; RegPhos
Y232MTKSGyQPPRLABL1RegPhos
S407KFRSPsDEGPGPhosphoSitePlus; phosphoELM; RegPhos
S324RSTHRsSSLGIPhosphoSitePlus
T165AQIGAtLARRLPkinasePhosphoSitePlus
S368DLRSSsPRKQLPhosphoSitePlus; phosphoELM; RegPhos
S366PRDLRsSSPRKPhosphoSitePlus; phosphoELM; RegPhos
S446PPPSTsSPHLTPhosphoSitePlus
S377QLSESsDDDYDPhosphoSitePlus
S586PIAHIsPHRLLphosphoELM; RegPhos
T451SSPHLtAHSEPPhosphoSitePlus
Y381SSDDDyDDVDIMAP4K1HPRD
T349LRGMEtRPPANPhosphoSitePlus
S444PGPPPsTSSPHPhosphoSitePlus
T175LSFIGtPYWMAPkinasePhosphoSitePlus
S377QLSESsDDDYDMAP4K1HPRD
S436GPPPNsPRPGPPhosphoSitePlus
T355RPPANtARLQPPhosphoSitePlus
S376KQLSEsSDDDYMAP4K1HPRD
S326THRSSsLGIPDPhosphoSitePlus
T165AQIGAtLARRLphosphoELM; RegPhos
S586PIAHIsPHRLLMAP4K1HPRD
S171LARRLsFIGTPphosphoELM; RegPhos
T599KNMVStKIQDTCNHPhosphoSitePlus
S598RKNMVsTKIQDCNHPhosphoSitePlus
Y381SSDDDyDDVDISykRegPhos
S407KFRSPsDEGPGMAP4K1HPRD
Y28LGGGTyGEVFKPkinasePhosphoSitePlus

Dephosphorylation site
M4K1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000380066P811LCOSMICOvarian Cancer21720365
ENSP00000380066R281*BIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
M4K1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M4K1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M4K1_HUMANM4K1_HUMANkinase -> substrateHPRD
M4K1_HUMANM3K11_HUMANkinase -> substrateKEGG; HPRD; RegPhos
M4K1_HUMANCAR11_HUMANkinase -> substrateNetPath
LYN_HUMANM4K1_HUMANkinase -> substrateHPRD; RegPhos
M4K1_HUMANM3KL4_HUMANkinase -> substrateRegPhos
M4K1_HUMANM3K10_HUMANkinase -> substrateRegPhos
M4K1_HUMANLCP2_HUMANkinase -> substrateRegPhos
ABL1_HUMANM4K1_HUMANkinase -> substrateHPRD; RegPhos
KSYK_HUMANM4K1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ZAGL2_HUMANM4K1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008349MAP kinase kinase kinase kinase activityIDAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005083small GTPase regulator activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0007257activation of JUN kinase activityTASbiological_process
GO:0006950response to stressIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0000185activation of MAPKKK activityICbiological_process
GO:0006950response to stressIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process