Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3KL4_HUMAN
Description:Mitogen-activated protein kinase kinase kinase MLK4 [Source:UniProtKB/Swiss-Prot;Acc:Q5TCX8]
Location:chr1 q42.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S732TVLLAsVALGLRegPhos
Y724TESALyGCTVLPhosphoSitePlus
S114PPSRPsSPVHVPhosphoSitePlus
S618LSDGNsPWSTIPhosphoSitePlus
Y96IFPANyVAPCRPhosphoSitePlus
S806ILSTPsFSTKCRegPhos
S517RISLPsDFQHKPhosphoSitePlus
T604QMKDRtDCKERPhosphoSitePlus
S546SSSPPsSPTMMHPRD
S543NSSSSsPPSSPPhosphoSitePlus; HPRD
T719PQRKKtESALYPhosphoSitePlus
S528ITVQAsPNLDKPhosphoSitePlus; HPRD
T142QVYRAtWQGQEPkinase_TyrPhosphoSitePlus
T592KKKGCtWGPNSPhosphoSitePlus
S773SKSRRsASPPTPhosphoSitePlus
S621GNSPWsTILIKPhosphoSitePlus
S303RTTKMsTAGTYHPK1(MAP4K1RegPhos
S455ALQQKsQEELLDUF3552PhosphoSitePlus
S111PAPPPsRPSSPPhosphoSitePlus
S547SSPPSsPTMMPRegPhos
S542LNSSSsSPPSSPhosphoSitePlus
S597TWGPNsIQMKDPhosphoSitePlus
S514DGHRIsLPSDFPhosphoSitePlus; HPRD
S303RTTKMsTAGTYautocatalysisRegPhos
Y47LWAALyDYEARSH3_1PhosphoSitePlus
S614RIRPLsDGNSPPhosphoSitePlus; HPRD; phosphoELM
T622NSPWStILIKNPhosphoSitePlus
S105CRPAAsPAPPPPhosphoSitePlus
T299REWHRtTKMSTautocatalysis RegPhos
Y669LPSQAyIDLPLPhosphoSitePlus

Dephosphorylation site
M3KL4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355583A392SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000355583H386RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000355583A922SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000355583E741DBIOMARTGastric Cancer21930507, 21930502
ENSP00000355583W310CDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000355583L729VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
M3KL4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3KL4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANM3KL4_HUMANkinase -> substrateRegPhos
M4K1_HUMANM3KL4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
M3KL4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007257activation of JUN kinase activityISSbiological_process
GO:0005575cellular_componentNDcellular_component
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0046777protein autophosphorylationISSbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0042803protein homodimerization activityISSmolecular_function
GO:0006468protein phosphorylationISSbiological_process


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