Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K10_HUMAN
Description:mitogen-activated protein kinase kinase kinase 10 [Source:HGNC Symbol;Acc:6849]
Location:chr19 q13.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S508PPASPsIIPRLPhosphoSitePlus
T558KKKGRtWGPSSPhosphoSitePlus
S489ITVQAsPTLDKPhosphoSitePlus; HPRD
S498DKRKGsDGASPPhosphoSitePlus
S262KTTKMsAAGTYautocatalysisRegPhos
S506ASPPAsPSIIPPhosphoSitePlus; RegPhos
S809KDPRQsLTPTHPhosphoSitePlus
S589KQWSSsAPNLGPhosphoSitePlus
S262KTTKMsAAGTYHPK1(MAP4K1RegPhos
S830HRRTPsDGALGPhosphoSitePlus
T258REWHKtTKMSAautocatalysis RegPhos
S502GSDGAsPPASPPhosphoSitePlus

Dephosphorylation site
M3K10_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000253055A884SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000253055R857HTCGAOvarian Cancer21720365, 18772890
ENSP00000253055G107EGreenman2007Skin Cancer17344846, 18428421
ENSP00000253055R463PDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000253055A233DTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
M3K10_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3K10_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K10_HUMANCEAM1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANM3K10_HUMANkinase -> substrateRegPhos
M4K1_HUMANM3K10_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
M3K10_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0046777protein autophosphorylationISSbiological_process
GO:0043425bHLH transcription factor bindingIPImolecular_function
GO:0007224smoothened signaling pathwayIMPbiological_process
GO:0003714transcription corepressor activityISSmolecular_function
GO:0043507positive regulation of JUN kinase activityIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0004706JUN kinase kinase kinase activityISSmolecular_function
GO:0006917induction of apoptosisTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0007256activation of JNKK activityISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0007254JNK cascadeTASbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenISSbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0018107peptidyl-threonine phosphorylationIDAbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042803protein homodimerization activityISSmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0043433negative regulation of sequence-specific DNA bindiIMPbiological_process
GO:0007257activation of JUN kinase activityISSbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0046330positive regulation of JNK cascadeIMPbiological_process


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