| UniProt/SwissProt ID: | LRIG1_HUMAN |
| Description: | leucine-rich repeats and immunoglobulin-like domains 1 [Source:HGNC Symbol;Acc:17360] |
| Location: | chr3 p14.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S332 | LAELSsLSVLR | LRR_4 | PhosphoSitePlus |
| Y1054 | RAEAQyLLVSN | PhosphoSitePlus | |
| T594 | HKARLtVNVLP | I-set | PhosphoSitePlus |
| S331 | SLAELsSLSVL | LRR_4 | PhosphoSitePlus |
| Y996 | CQGSLyPSNHD | PhosphoSitePlus | |
| T602 | VLPSFtKTPHD | I-set | PhosphoSitePlus |
| Y941 | TEVDCySRGQA | PhosphoSitePlus | |
| Y1029 | TLARLyHPDST | PhosphoSitePlus | |
| S259 | AFWGLsKMHVL | PhosphoSitePlus | |
| S600 | VNVLPsFTKTP | I-set | PhosphoSitePlus |
| S334 | ELSSLsVLRLS | LRR_4 | PhosphoSitePlus |
| Dephosphorylation site |
| LRIG1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000373208 | T283M | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000273261 | T283M | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000273261 | Prostate Cancer | Treatment (androgen-starved vs. androgen-stimulated) | cell line | Up | 3.6 | 14729644 |
| Hyperphosphorylation site |
| LRIG1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK5_HUMAN | LRIG1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | LRIG1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CSK21_HUMAN | LRIG1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| CSK22_HUMAN | LRIG1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | LRIG1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | LRIG1_HUMAN | kinase -> substrate | RegPhos |
| CDK6_HUMAN | LRIG1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CHK2_HUMAN | LRIG1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK3_HUMAN | LRIG1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | LRIG1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BUB1_HUMAN | LRIG1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| LRIG1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |