Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KCC2B_HUMAN
Description:calcium/calmodulin-dependent protein kinase II beta [Source:HGNC Symbol;Acc:1461]
Location:chr7 p13
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y231IKAGAyDFPSPPkinase_CAMKPhosphoSitePlus
T356ALEPQtTVIHNHPRD
S235AYDFPsPEWDTPkinase_CAMKPhosphoSitePlus
T358LEPQTtVIHNPHPRD
T287MHRQEtVECLKCAMK2BHPRD
S394DGIKEsSDSANPhosphoSitePlus; HPRD
T357ALEPQtTVIHNHPRD
T358KEPQTtVIHNPHPRD
S327APATMsTAASGHPRD
T357LEPQTtVIHNPHPRD
T506RRGSGtPEAEGPhosphoSitePlus
S280RSTVAsMMHRQPhosphoSitePlus
S367SAAATsPKGTLRegPhos
T357VKEPQtTVIHNHPRD
S369DGIKEsSDSANHPRD
S522PPPCPsPTIPGPhosphoSitePlus
S441SPAPFsPLPAPPhosphoSitePlus
T463RRGSGtPEAEGPhosphoSitePlus
S370DGIKEsSDSANHPRD
S456SDILNsVRRGSPhosphoSitePlus
S461SVRRGsGTPEAPhosphoSitePlus
S471AEGPLsAGPPPPhosphoSitePlus
S499SDILNsVRRGSPhosphoSitePlus
T311TTMLAtRNFSVPhosphoSitePlus
T306KGAILtTMLATPhosphoSitePlus
S315ATRNFsVGRQTPhosphoSitePlus; HPRD; RegPhos
S395GIKESsDSANTPhosphoSitePlus
T307GAILTtMLATRPhosphoSitePlus
S276WVCQRsTVASMPhosphoSitePlus
T287MHRQEtVECLKCaMK2bRegPhos
T382LEPQTtVIHNPHPRD
T381ALEPQtTVIHNHPRD
S504SVRRGsGTPEAPhosphoSitePlus
Y17DEYQLyEDIGKRegPhos
S423SVRRGsGAPEAPhosphoSitePlus
T320SVGRQtTAPATHPRD
S315ATRNFsAKSLLHPRD
S397KESSDsANTTIRegPhos
T287MHRQEtVECLKPhosphoSitePlus; RegPhos

Dephosphorylation site
KCC2B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379098P489LHPIColorectal Cancer17344846
ENSP00000379098*667YCOSMICOvarian Cancer21720365
ENSP00000379098P489LGreenman2007Intestines Cancer17344846, 18428421

Differential expressed protein
KCC2B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KCC2B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC2B_HUMANNMDE2_HUMANkinase -> substrateHPRD
KCC2B_HUMANPLCB3_HUMANkinase -> substrateHPRD
KCC2B_HUMANCO4A3_HUMANkinase -> substrateHPRD
KCC2B_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
KCC2B_HUMANETS1_HUMANkinase -> substrateHPRD
KCC2B_HUMANNMDE1_HUMANkinase -> substrateHPRD
KCC2B_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
KCC2B_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
KCC2B_HUMANSMAD2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANKCC2B_HUMANkinase -> substrateRegPhos
KCC2B_HUMANKCC2B_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05031Amphetamine addiction
hsa04012ErbB signaling pathway
hsa04912GnRH signaling pathway
hsa04310Wnt signaling pathway
hsa04916Melanogenesis
hsa04725Cholinergic synapse
hsa04720Long-term potentiation
hsa05152Tuberculosis
hsa04740Olfactory transduction
hsa04722Neurotrophin signaling pathway
hsa04114Oocyte meiosis
hsa05214Glioma
hsa04728Dopaminergic synapse
hsa04971Gastric acid secretion
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0061003positive regulation of dendritic spine morphogenesISSbiological_process
GO:0002030inhibitory G-protein coupled receptor phosphorylatIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0051823regulation of synapse structural plasticityTASbiological_process
GO:0030666endocytic vesicle membraneTAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0046686response to cadmium ionIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0032222regulation of synaptic transmission, cholinergicIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005815microtubule organizing centerIEAcellular_component
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0006816calcium ion transportIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0010976positive regulation of neuron projection developmeISSbiological_process
GO:0051233spindle midzoneIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0060998regulation of dendritic spine developmentTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0004683calmodulin-dependent protein kinase activityIEAmolecular_function
GO:0048169regulation of long-term neuronal synaptic plasticiIEAbiological_process
GO:0003779actin bindingIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0014733regulation of skeletal muscle adaptationTASbiological_process
GO:0050885neuromuscular process controlling balanceIEAbiological_process
GO:0060466activation of meiosis involved in egg activationIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0048169regulation of long-term neuronal synaptic plasticiTASbiological_process
GO:2001235positive regulation of apoptotic signaling pathwayIEAbiological_process
GO:0090129positive regulation of synapse maturationISSbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0051924regulation of calcium ion transportTASbiological_process
GO:0033017sarcoplasmic reticulum membraneIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005516calmodulin bindingIEAmolecular_function