Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRK6_HUMAN
Description:potassium inwardly-rectifying channel, subfamily J, member 6 [Source:HGNC Symbol;Acc:6267]
Location:chr21 q22.13
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T78TYRYLtDIFTTPhosphoSitePlus
S212THAVIsMRDGKPhosphoSitePlus
T202KKRAEtLVFSTPhosphoSitePlus

Dephosphorylation site
IRK6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000383330F336LCOSMICSkin Cancer21984974
ENSP00000383330D79NCOSMICMelanoma21499247
ENSP00000383330V159GCOSMICOvarian Cancer21720365
ENSP00000383330S179FCOSMICSkin Cancer21984974

Differential expressed protein
IRK6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IRK6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG13_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBG2_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBG1_HUMANIRK6_HUMANGprotein -> effectorgpDB
GNAI3_HUMANIRK6_HUMANGprotein -> effectorgpDB
GNAI2_HUMANIRK6_HUMANGprotein -> effectorgpDB
GNAI1_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBB1_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBG3_HUMANIRK6_HUMANGprotein -> effectorgpDB
GNAQ_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBG11_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBB3_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBB5_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBG12_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBG5_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBG8_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBG10_HUMANIRK6_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04728Dopaminergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa05032Morphine addiction
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0015467G-protein activated inward rectifier potassium chaIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0006813potassium ion transportTASbiological_process
GO:0008076voltage-gated potassium channel complexTAScellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0005242inward rectifier potassium channel activityTASmolecular_function


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