Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL8_HUMAN
Description:interleukin 8 [Source:HGNC Symbol;Acc:6025]
Location:chr4 q13.3
Node attribute:PPI(target); PPI(source); ligand; gene

Phosphorylation site
IL8_HUMAN do not have phosphorylation site.

Dephosphorylation site
IL8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000306512L32HTCGAOvarian Cancer21720365, 18772890
ENSP00000306512C61*COSMICOvarian Cancer21720365
ENSP00000306512L32HCOSMICOvarian Cancer21720365

Differential expressed protein
IL8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IL8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IL8_HUMANCXCR1_HUMANligand -> receptorHPMR
IL8_HUMANCXCR2_HUMANligand -> receptorHPMR
IL8_HUMANCXCR2_HUMANotherKEGG
IL8_HUMANCXCR1_HUMANotherKEGG
FOS_HUMANIL8_HUMANotherKEGG
NFKB1_HUMANIL8_HUMANotherKEGG
IRF5_HUMANIL8_HUMANotherKEGG
NFKB1_HUMANIL8_HUMANTF -> target geneKEGG
JUN_HUMANIL8_HUMANTF -> target geneKEGG
MK14_HUMANIL8_HUMANTF -> target geneKEGG
CRTC3_HUMANIL8_HUMANTF -> target geneTRANSFAC
CRTC2_HUMANIL8_HUMANTF -> target geneTRANSFAC
FOS_HUMANIL8_HUMANTF -> target geneTRANSFAC
CRTC1_HUMANIL8_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04621NOD-like receptor signaling pathway
hsa05133Pertussis
hsa05200Pathways in cancer
hsa05144Malaria
hsa04062Chemokine signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05160Hepatitis C
hsa05142Chagas disease (American trypanosomiasis)
hsa05131Shigellosis
hsa05164Influenza A
hsa04060Cytokine-cytokine receptor interaction
hsa04622RIG-I-like receptor signaling pathway
hsa05323Rheumatoid arthritis
hsa04064NF-kappa B signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa05219Bladder cancer
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa05146Amoebiasis
hsa05134Legionellosis
hsa05132Salmonella infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019722calcium-mediated signalingTASbiological_process
GO:0034976response to endoplasmic reticulum stressIDAbiological_process
GO:0071356cellular response to tumor necrosis factorIEPbiological_process
GO:0030155regulation of cell adhesionIDAbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0008009chemokine activityIEAmolecular_function
GO:0044344cellular response to fibroblast growth factor stimIEPbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0042119neutrophil activationTASbiological_process
GO:0005153interleukin-8 receptor bindingIPImolecular_function
GO:0005576extracellular regionIEAcellular_component
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0007050cell cycle arrestIDAbiological_process
GO:0045744negative regulation of G-protein coupled receptor IDAbiological_process
GO:0001525angiogenesisTASbiological_process
GO:0006955immune responseIEAbiological_process
GO:0071222cellular response to lipopolysaccharideIDAbiological_process
GO:0048566embryonic digestive tract developmentIEPbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0090023positive regulation of neutrophil chemotaxisTASbiological_process
GO:0035556intracellular signal transductionIDAbiological_process
GO:0031623receptor internalizationIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071347cellular response to interleukin-1IEPbiological_process
GO:0006928cellular component movementTASbiological_process
GO:0030593neutrophil chemotaxisIGIbiological_process
GO:0002237response to molecule of bacterial originIDAbiological_process
GO:0045091regulation of retroviral genome replicationIDAbiological_process
GO:0050930induction of positive chemotaxisIGIbiological_process


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