| UniProt/SwissProt ID: | IL8_HUMAN |
| Description: | interleukin 8 [Source:HGNC Symbol;Acc:6025] |
| Location: | chr4 q13.3 |
| Node attribute: | PPI(target); PPI(source); ligand; gene |
| Phosphorylation site |
| IL8_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| IL8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000306512 | L32H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000306512 | C61* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000306512 | L32H | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| IL8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IL8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IL8_HUMAN | CXCR1_HUMAN | ligand -> receptor | HPMR |
| IL8_HUMAN | CXCR2_HUMAN | ligand -> receptor | HPMR |
| IL8_HUMAN | CXCR2_HUMAN | other | KEGG |
| IL8_HUMAN | CXCR1_HUMAN | other | KEGG |
| FOS_HUMAN | IL8_HUMAN | other | KEGG |
| NFKB1_HUMAN | IL8_HUMAN | other | KEGG |
| IRF5_HUMAN | IL8_HUMAN | other | KEGG |
| NFKB1_HUMAN | IL8_HUMAN | TF -> target gene | KEGG |
| JUN_HUMAN | IL8_HUMAN | TF -> target gene | KEGG |
| MK14_HUMAN | IL8_HUMAN | TF -> target gene | KEGG |
| CRTC3_HUMAN | IL8_HUMAN | TF -> target gene | TRANSFAC |
| CRTC2_HUMAN | IL8_HUMAN | TF -> target gene | TRANSFAC |
| FOS_HUMAN | IL8_HUMAN | TF -> target gene | TRANSFAC |
| CRTC1_HUMAN | IL8_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04621 | NOD-like receptor signaling pathway |
| hsa05133 | Pertussis |
| hsa05200 | Pathways in cancer |
| hsa05144 | Malaria |
| hsa04062 | Chemokine signaling pathway |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa05160 | Hepatitis C |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa05131 | Shigellosis |
| hsa05164 | Influenza A |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa05323 | Rheumatoid arthritis |
| hsa04064 | NF-kappa B signaling pathway |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05219 | Bladder cancer |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori i |
| hsa05146 | Amoebiasis |
| hsa05134 | Legionellosis |
| hsa05132 | Salmonella infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019722 | calcium-mediated signaling | TAS | biological_process |
| GO:0034976 | response to endoplasmic reticulum stress | IDA | biological_process |
| GO:0071356 | cellular response to tumor necrosis factor | IEP | biological_process |
| GO:0030155 | regulation of cell adhesion | IDA | biological_process |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0006987 | activation of signaling protein activity involved | TAS | biological_process |
| GO:0008009 | chemokine activity | IEA | molecular_function |
| GO:0044344 | cellular response to fibroblast growth factor stim | IEP | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0042119 | neutrophil activation | TAS | biological_process |
| GO:0005153 | interleukin-8 receptor binding | IPI | molecular_function |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0030968 | endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0007050 | cell cycle arrest | IDA | biological_process |
| GO:0045744 | negative regulation of G-protein coupled receptor | IDA | biological_process |
| GO:0001525 | angiogenesis | TAS | biological_process |
| GO:0006955 | immune response | IEA | biological_process |
| GO:0071222 | cellular response to lipopolysaccharide | IDA | biological_process |
| GO:0048566 | embryonic digestive tract development | IEP | biological_process |
| GO:0006954 | inflammatory response | TAS | biological_process |
| GO:0090023 | positive regulation of neutrophil chemotaxis | TAS | biological_process |
| GO:0035556 | intracellular signal transduction | IDA | biological_process |
| GO:0031623 | receptor internalization | IDA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0071347 | cellular response to interleukin-1 | IEP | biological_process |
| GO:0006928 | cellular component movement | TAS | biological_process |
| GO:0030593 | neutrophil chemotaxis | IGI | biological_process |
| GO:0002237 | response to molecule of bacterial origin | IDA | biological_process |
| GO:0045091 | regulation of retroviral genome replication | IDA | biological_process |
| GO:0050930 | induction of positive chemotaxis | IGI | biological_process |