Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL2_HUMAN
Description:interleukin 2 [Source:HGNC Symbol;Acc:6001]
Location:chr4 q27
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S8RMQLLsCIALSIL2PhosphoSitePlus
Y65LTFKFyMPKKAIL2PhosphoSitePlus

Dephosphorylation site
IL2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000226730L76FCOSMICMelanoma21499247

Differential expressed protein
IL2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PO2F2_HUMANIL2_HUMANTF -> target geneTRANSFAC
FOXK2_HUMANIL2_HUMANTF -> target geneTRANSFAC
ELF1_HUMANIL2_HUMANTF -> target geneTRANSFAC
JUN_HUMANIL2_HUMANTF -> target geneTRANSFAC
EGR1_HUMANIL2_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANIL2_HUMANTF -> target geneTRANSFAC
FOXN2_HUMANIL2_HUMANTF -> target geneTRANSFAC
FOS_HUMANIL2_HUMANTF -> target geneTRANSFAC
FOXP3_HUMANIL2_HUMANTF -> target geneTRANSFAC
PO6F1_HUMANIL2_HUMANTF -> target geneTRANSFAC
SP1_HUMANIL2_HUMANTF -> target geneTRANSFAC
ZEB1_HUMANIL2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
IL2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032729positive regulation of interferon-gamma productionIEAbiological_process
GO:0030217T cell differentiationTASbiological_process
GO:0008083growth factor activityTASmolecular_function
GO:0007205protein kinase C-activating G-protein coupled receIEAbiological_process
GO:0045582positive regulation of T cell differentiationIEAbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0005615extracellular spaceTAScellular_component
GO:0006955immune responseTASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0050672negative regulation of lymphocyte proliferationIEAbiological_process
GO:0030101natural killer cell activationTASbiological_process
GO:0005134interleukin-2 receptor bindingIEAmolecular_function
GO:0005134interleukin-2 receptor bindingTASmolecular_function
GO:0050728negative regulation of inflammatory responseIEAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0042104positive regulation of activated T cell proliferatIEAbiological_process
GO:0043208glycosphingolipid bindingIEAmolecular_function
GO:0042523positive regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0042102positive regulation of T cell proliferationIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0030890positive regulation of B cell proliferationIDAbiological_process
GO:0042523positive regulation of tyrosine phosphorylation ofIEAbiological_process
GO:0051024positive regulation of immunoglobulin secretionIEAbiological_process
GO:0045822negative regulation of heart contractionIEAbiological_process
GO:0001933negative regulation of protein phosphorylationIEAbiological_process
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0045591positive regulation of regulatory T cell differentIEAbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0050729positive regulation of inflammatory responseICbiological_process
GO:0005125cytokine activityIDAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0019209kinase activator activityTASmolecular_function
GO:0002903negative regulation of B cell apoptotic processIDAbiological_process
GO:0042104positive regulation of activated T cell proliferatIDAbiological_process
GO:0046013regulation of T cell homeostatic proliferationIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0031851kappa-type opioid receptor bindingIEAmolecular_function
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0034105positive regulation of tissue remodelingICbiological_process
GO:0030307positive regulation of cell growthTASbiological_process
GO:0060999positive regulation of dendritic spine developmentIEAbiological_process
GO:0032740positive regulation of interleukin-17 productionIDAbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0048304positive regulation of isotype switching to IgG isIEAbiological_process
GO:0030246carbohydrate bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process