Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL2RA_HUMAN
Description:interleukin 2 receptor, alpha [Source:HGNC Symbol;Acc:6008]
Location:chr10 p15.1
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S268RRQRKsRRPKC_groupphosphoELM
T271RKSRRPKC_groupphosphoELM
T271RKSRRtI____PhosphoSitePlus
S268RRQRKsRRHPRD
S268RRQRKsRRTI_PhosphoSitePlus
T271RKSRRHPRD

Dephosphorylation site
IL2RA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000369293Y239*COSMICMelanoma21499247
ENSP00000369293R176KCOSMICOvarian Cancer21720365

Differential expressed protein
IL2RA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IL2RA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ELF1_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
TF65_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
REL_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
STA5A_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
STA5B_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
STAT3_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
STAT6_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
STAT4_HUMANIL2RA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
IL2RA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0042102positive regulation of T cell proliferationIEAbiological_process
GO:0045582positive regulation of T cell differentiationIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0042104positive regulation of activated T cell proliferatIEAbiological_process
GO:0043029T cell homeostasisIEAbiological_process
GO:0019976interleukin-2 bindingIEAmolecular_function
GO:0006955immune responseTASbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0038110interleukin-2-mediated signaling pathwayIEAbiological_process
GO:0046013regulation of T cell homeostatic proliferationIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0042130negative regulation of T cell proliferationIEAbiological_process
GO:0008144drug bindingIEAmolecular_function
GO:0050777negative regulation of immune responseIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0050687negative regulation of defense response to virusIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0050728negative regulation of inflammatory responseIEAbiological_process
GO:0006924activation-induced cell death of T cellsIEAbiological_process
GO:0050672negative regulation of lymphocyte proliferationIEAbiological_process
GO:0004911interleukin-2 receptor activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0002437inflammatory response to antigenic stimulusIEAbiological_process


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