| UniProt/SwissProt ID: | TTC1_HUMAN |
| Description: | tetratricopeptide repeat domain 1 [Source:HGNC Symbol;Acc:12391] |
| Location: | chr5 q33.3 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y280 | SSTGSySINFV | A2M_N | PhosphoSitePlus |
| S90 | EDVNSsELDEE | PhosphoSitePlus; HPRD; phosphoELM | |
| S69 | HDCSAsFEEEP | PhosphoSitePlus; HPRD; phosphoELM | |
| S281 | STGSYsINFVQ | A2M_N | PhosphoSitePlus |
| S83 | KVENKsNEDVN | PhosphoSitePlus; HPRD; phosphoELM | |
| S89 | NEDVNsSELDE | PhosphoSitePlus; HPRD; phosphoELM | |
| S67 | CFHDCsASFEE | PhosphoSitePlus; HPRD; phosphoELM | |
| S41 | PKNQHsQSKLL | PhosphoSitePlus; HPRD | |
| Y96 | ELDEEyLIELE | PhosphoSitePlus | |
| Dephosphorylation site |
| TTC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000429225 | A228V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000231238 | A228V | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000231238 | Breast Cancer | Metastasis | cell line | Down | 0.7 | 18582095 |
| Hyperphosphorylation site |
| TTC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNAQ_HUMAN | TTC1_HUMAN | Gprotein -> effector | gpDB |
| GNA15_HUMAN | TTC1_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| TTC1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005778 | peroxisomal membrane | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051082 | unfolded protein binding | NAS | molecular_function |
| GO:0006457 | protein folding | NAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |