| UniProt/SwissProt ID: | PLCB4_HUMAN |
| Description: | phospholipase C, beta 4 [Source:HGNC Symbol;Acc:9059] |
| Location: | chr20 p12.3 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T1021 | IVAQHtKEWSE | PhosphoSitePlus | |
| Y623 | QMSRIyPKGGR | HPRD | |
| Y721 | KKIGTyVEVDM | C2 | PhosphoSitePlus |
| S890 | VTPQSsSELRP | PhosphoSitePlus; HPRD; phosphoELM | |
| S867 | IADVPsDTSKN | PhosphoSitePlus | |
| T886 | AKANVtPQSSS | PhosphoSitePlus | |
| T1004 | EIKIQtLTSDH | PhosphoSitePlus | |
| T998 | EMKKEtEIKIQ | PhosphoSitePlus | |
| S620 | NKRQMsRIYPK | HPRD | |
| Dephosphorylation site |
| PLCB4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000334105 | T898M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000367762 | P165L | COSMIC | Melanoma | 21499247 | ENSP00000367762 | R254Q | COSMIC | Pancreatic Cancer | ENSP00000334105 | S342L | COSMIC | Melanoma | 21499247 | ENSP00000278655 | K933N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000367762 | H1159N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000334105 | R760W | COSMIC | Melanoma | 21499247 | ENSP00000334105 | E737K | COSMIC | Melanoma | 21499247 | ENSP00000367762 | D496N | COSMIC | Melanoma | 21499247 | ENSP00000278655 | T898M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000367762 | E1086K | COSMIC | Melanoma | 21499247 | ENSP00000334105 | N1192H | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000334105 | L83P | COSMIC | Melanoma | 21499247 | ENSP00000367754 | T898M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000334105 | G95W | COSMIC | Skin Cancer | 21984974 | ENSP00000334105 | E1086K | COSMIC | Melanoma | 21499247 | ENSP00000334105 | K933N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000367762 | S342L | COSMIC | Melanoma | 21499247 | ENSP00000367762 | M1I | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000367762 | R760W | COSMIC | Melanoma | 21499247 | ENSP00000334105 | M1I | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000367762 | K933N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000334105 | D496N | COSMIC | Melanoma | 21499247 | ENSP00000367762 | T898M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000367754 | K933N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000367762 | L83P | COSMIC | Melanoma | 21499247 | ENSP00000334105 | P165L | COSMIC | Melanoma | 21499247 | ENSP00000334105 | R251Q | COSMIC | Melanoma | 21499247 | ENSP00000334105 | R254Q | COSMIC | Pancreatic Cancer | ENSP00000334105 | H1159N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000367762 | R251Q | COSMIC | Melanoma | 21499247 | ENSP00000367762 | G95W | COSMIC | Skin Cancer | 21984974 | ENSP00000367762 | E737K | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| PLCB4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PLCB4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNAQ_HUMAN | PLCB4_HUMAN | Gprotein -> effector | gpDB |
| GNA11_HUMAN | PLCB4_HUMAN | Gprotein -> effector | gpDB |
| GNA15_HUMAN | PLCB4_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa01100 | Metabolic pathways |
| hsa04728 | Dopaminergic synapse |
| hsa04720 | Long-term potentiation |
| hsa04961 | Endocrine and other factor-regulated calcium reabs |
| hsa05010 | Alzheimer's disease |
| hsa00562 | Inositol phosphate metabolism |
| hsa04726 | Serotonergic synapse |
| hsa04916 | Melanogenesis |
| hsa05146 | Amoebiasis |
| hsa04725 | Cholinergic synapse |
| hsa04971 | Gastric acid secretion |
| hsa05016 | Huntington's disease |
| hsa04062 | Chemokine signaling pathway |
| hsa04730 | Long-term depression |
| hsa04310 | Wnt signaling pathway |
| hsa04070 | Phosphatidylinositol signaling system |
| hsa04020 | Calcium signaling pathway |
| hsa04724 | Glutamatergic synapse |
| hsa04970 | Salivary secretion |
| hsa05143 | African trypanosomiasis |
| hsa04972 | Pancreatic secretion |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa04912 | GnRH signaling pathway |
| hsa04540 | Gap junction |
| hsa04270 | Vascular smooth muscle contraction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004435 | phosphatidylinositol phospholipase C activity | IEA | molecular_function |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0016042 | lipid catabolic process | IEA | biological_process |
| GO:0008081 | phosphoric diester hydrolase activity | IEA | molecular_function |
| GO:0004629 | phospholipase C activity | TAS | molecular_function |
| GO:0014069 | postsynaptic density | IEA | cellular_component |
| GO:0005790 | smooth endoplasmic reticulum | IEA | cellular_component |
| GO:0030425 | dendrite | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006629 | lipid metabolic process | IEA | biological_process |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |