Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GNA15_HUMAN
Description:guanine nucleotide binding protein (G protein), alpha 15 (Gq class) [Source:HGNC Symbol;Acc:4383]
Location:chr19 p13.3
Node attribute:Gprotein; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S336KKGARsRRLFSPKCaRegPhos
S336KKGARsRRLFSG-alphaPhosphoSitePlus
S336KKGARsRRLFSPRKCAHPRD
S336KKGARsRRLFSPKC_groupphosphoELM; RegPhos

Dephosphorylation site
GNA15_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262958E173KCOSMICMelanoma21499247
ENSP00000262958P301SCOSMICMelanoma20424519
ENSP00000262958R366CCOSMICMelanoma21499247
ENSP00000262958E328KCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000262958Breast CancerNormal vs. Cancercell lineDown0.0220198662

Hyperphosphorylation site
GNA15_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNA15_HUMANTTC1_HUMANGprotein -> effectorgpDB
GNA15_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GNA15_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GNA15_HUMANPLCB4_HUMANGprotein -> effectorgpDB
GNA15_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GNA15_HUMANGRK6_HUMANGprotein -> effectorgpDB
KPCA_HUMANGNA15_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05146Amoebiasis
hsa05142Chagas disease (American trypanosomiasis)
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003924GTPase activityTASmolecular_function
GO:0004871signal transducer activityIGImolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0031234extrinsic to internal side of plasma membraneIBAcellular_component
GO:0019001guanyl nucleotide bindingIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0006184GTP catabolic processTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0006471protein ADP-ribosylationIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0007204elevation of cytosolic calcium ion concentrationIGIbiological_process
GO:0060158phospholipase C-activating dopamine receptor signaIBAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007207phospholipase C-activating G-protein coupled acetyTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0001664G-protein coupled receptor bindingIBAmolecular_function
GO:0031683G-protein beta/gamma-subunit complex bindingIBAmolecular_function
GO:0007188adenylate cyclase-modulating G-protein coupled recIBAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepIEAbiological_process
GO:0005834heterotrimeric G-protein complexIBAcellular_component
GO:0005525GTP bindingNASmolecular_function


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