| UniProt/SwissProt ID: | GABR1_HUMAN |
| Description: | gamma-aminobutyric acid (GABA) B receptor, 1 [Source:HGNC Symbol;Acc:4070] |
| Location: | chrHSCHR6_MHC_APD p2 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S879 | MKTGSsTNNNE | HPRD | |
| T818 | KTGSStNNNEE | HPRD | |
| S816 | TMKTGsSTNNN | HPRD | |
| T930 | RRHPPtPPEPS | PhosphoSitePlus | |
| S762 | MKTGSsTNNNE | HPRD | |
| S761 | TMKTGsSTNNN | HPRD | |
| Y776 | GIFYGyKGLLL | 7tm_3; TM | PhosphoSitePlus |
| T880 | KTGSStNNNEE | HPRD | |
| T759 | QDTMKtGSSTN | HPRD | |
| S878 | TMKTGsSTNNN | HPRD | |
| Y209 | DILPDyELKLI | ANF_receptor | PhosphoSitePlus |
| T876 | QDTMKtGSSTN | HPRD | |
| T814 | QDTMKtGSSTN | HPRD | |
| S817 | MKTGSsTNNNE | HPRD | |
| T763 | KTGSStNNNEE | HPRD | |
| Dephosphorylation site |
| GABR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000419061 | R329* | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000366211 | R212* | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000348248 | R212* | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000366176 | R329* | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000366215 | R267* | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000366233 | R329* | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| GABR1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GABR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DCE1_HUMAN | GABR1_HUMAN | ligand -> receptor | HPMR |
| GABR1_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| GABR1_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| GABR1_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| GABR1_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05032 | Morphine addiction |
| hsa04727 | GABAergic synapse |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0038037 | G-protein coupled receptor dimeric complex | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | IEA | biological_process |
| GO:0030054 | cell junction | IEA | cellular_component |
| GO:0004965 | G-protein coupled GABA receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0045211 | postsynaptic membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0042734 | presynaptic membrane | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007194 | negative regulation of adenylate cyclase activity | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |