Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FINC_HUMAN
Description:fibronectin 1 [Source:HGNC Symbol;Acc:3778]
Location:chr2 q35
Node attribute:PPI(source); ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1842KTETItGFQVDfn3PhosphoSitePlus
T1762TPKEKtGPMKEfn3PhosphoSitePlus
Y1206PDITGyRITTTfn3PhosphoSitePlus
T136GRISCtIANRCPhosphoSitePlus
S2384ADREDsRE___PhosphoSitePlus; SysPTM
S2354SYNQYsQRYHQPhosphoSitePlus
Y641SHISKyILRWRfn3PhosphoSitePlus
T1840RTKTEtITGFQfn3PhosphoSitePlus
S2353ADREDsHPRD
S2294ADREDsHPRD
Y372NGRTFySCTTEfn2PhosphoSitePlus
T1743LSAQWtPPNVQfn3PhosphoSitePlus
S909SDTVPsPRDLQHPRD; SysPTM
S1833TTITIsWRTKTfn3PhosphoSitePlus
S968EVTGLsPGVTYfn3PhosphoSitePlus
T960PISRNtFAEVTfn3PhosphoSitePlus
Y1042GQPRQyNVGPSfn3PhosphoSitePlus
S2285PGGEPsPEGTTHPRD
T1860TPIQRtIKPDVfn3PhosphoSitePlus
Y937SAVTGyRVDVIfn3PhosphoSitePlus
Y1884YKIYLyTLNDNfn3PhosphoSitePlus
S2310PGGEPsPEGTTHPRD
S2259GTTGQsYNQYSHPRD
S2251PGGEPsPEGTTHPRD
Y2353QSYNQySQRYHPhosphoSitePlus
T972LSPGVtYYFKVfn3PhosphoSitePlus
Y106YTGNTyRVGDTfn1PhosphoSitePlus
S2432PGGEPsPEGTTHPRD
S2328ADREDsHPRD
S2131PGGEPsPEGTTHPRD
S2440GTTGQsYNQYSHPRD
Y588VRYQCyCYGRGfn1PhosphoSitePlus
S904TGTPRsDTVPSPhosphoSitePlus; HPRD
S2139GTTGQsYNQYSHPRD
S2293GTTGQsYNQYSHPRD
S2174ADREDsHPRD
Y1879QPGTDyKIYLYfn3PhosphoSitePlus
T1271AVPPPtDLRFTfn3PhosphoSitePlus
T1855PANGQtPIQRTfn3PhosphoSitePlus
Y2258DNGVNyKIGEKfn1PhosphoSitePlus
Y101TCFDKyTGNTYfn1PhosphoSitePlus
S2318GTTGQsYNQYSHPRD
Y2350TTGQSyNQYSQPhosphoSitePlus
S2475ADREDsHPRD
T1786GLMVAtKYEVSfn3PhosphoSitePlus
T2065R.RTTPPTTATPIR.HSysPTM 2.0
T2067R.RTTPPTTATPIR.HSysPTM 2.0

Dephosphorylation site
FINC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000352696D2380NHPIColorectal Cancer16959974
ENSP00000399538C386FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000338200R1120PSjoblom2006, COSMICBreast Cancer16959974
ENSP00000338200D2349NSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000338200T2132SCOSMICOvarian Cancer21720365
ENSP00000338200P363SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000338200N104SCOSMICCentral Nervous System Neoplasms18772396
ENSP00000338200A1902VCOSMICCentral Nervous System Neoplasms
ENSP00000338200P910LCOSMICSkin Cancer21984974
ENSP00000338200Q2169*COSMICIntestines Cancer16959974
ENSP00000338200K2019MCOSMICHead and Neck Cancer21798893
ENSP00000338200P300SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000338200D940NSjoblom2006, COSMICBreast Cancer16959974
ENSP00000338200Q2169XBIOMARTColorectal Cancer21930507, 21930502
ENSP00000338200G264SCOSMICHead and Neck Cancer21798893
ENSP00000338200H2211RCOSMICPancreatic Cancer
ENSP00000352696D940NSjoblom2006, HPIBreast Cancer16959974
ENSP00000338200A1899TCOSMICCentral Nervous System Neoplasms
ENSP00000352696R1120PSjoblom2006, HPIBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000352696hepatitis C virusNormal vs. CancertissueUp3.418715028
ENSP00000352696hepatitis C virusNormal vs. CancertissueUp4.918715028
ENSP00000352696hepatitis B virusNormal vs. CancertissueDown0.1614726492
ENSP00000352696hepatitis B virusNormal vs. CancertissueDown0.3214726492
ENSP00000352696Lung CancerNormal vs. CancertissueUp217705522
ENSP00000352696Pancreatic CancerNormal vs. CancertissueDown0.0516215274
ENSP00000352696Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000352696Breast CancerMetastasistissueDown0.419053527
ENSP00000352696Oral CancerNormal vs. CancertissueUp9.919297561
ENSP00000352696Hepatocellular CarcinomaNormal vs. CancertissueUp18571811
ENSP00000352696Hepatocellular CarcinomaMetastasiscell lineUp2.219016532
ENSP00000352696Breast CancerNormal vs. Cancercell lineDown0.0220198662
ENSP00000352696Breast CancerMetastasiscell lineDown0.320198662
ENSP00000352696Breast CancerNormal vs. CancertissueUp0.9920739354
ENSP00000352696Breast CancerNormal vs. CancertissueUp0.9920739354
ENSP00000352696Renal CancerNormal vs. CancertissueUp19164279
ENSP00000352696Ovarian CancerMetastasiscell lineDown0.1117892554
ENSP00000352696Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueUp3.319422301
ENSP00000352696Pancreatic CancerNormal vs. CancertissueUp2.416230073

Hyperphosphorylation site
FINC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FINC_HUMANITB8_HUMANligand -> receptorHPMR
FINC_HUMANSDC1_HUMANotherKEGG
FINC_HUMANCD44_HUMANotherKEGG
ATF2_HUMANFINC_HUMANTF -> target geneTRANSFAC
CREB1_HUMANFINC_HUMANTF -> target geneTRANSFAC
JUN_HUMANFINC_HUMANTF -> target geneTRANSFAC
NFIC_HUMANFINC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05222Small cell lung cancer
hsa05100Bacterial invasion of epithelial cells
hsa04510Focal adhesion
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa04512ECM-receptor interaction
hsa05146Amoebiasis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005793endoplasmic reticulum-Golgi intermediate compartmeIDAcellular_component
GO:0016504peptidase activator activityIEAmolecular_function
GO:0005578proteinaceous extracellular matrixNAScellular_component
GO:0010952positive regulation of peptidase activityIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0050900leukocyte migrationTASbiological_process
GO:0006953acute-phase responseIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0005518collagen bindingNASmolecular_function
GO:0016477cell migrationNASbiological_process
GO:0005604basement membraneIEAcellular_component
GO:0008201heparin bindingNASmolecular_function
GO:0002576platelet degranulationTASbiological_process
GO:0034446substrate adhesion-dependent cell spreadingIDAbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0007044cell-substrate junction assemblyIEAbiological_process
GO:0005577fibrinogen complexIDAcellular_component
GO:0031012extracellular matrixIDAcellular_component
GO:0016324apical plasma membraneIEAcellular_component
GO:0007161calcium-independent cell-matrix adhesionIEAbiological_process
GO:0018149peptide cross-linkingIDAbiological_process
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0007155cell adhesionNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005201extracellular matrix structural constituentNASmolecular_function
GO:0031012extracellular matrixIEAcellular_component
GO:0008360regulation of cell shapeIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0042060wound healingIEAbiological_process
GO:0009611response to woundingNASbiological_process
GO:0001525angiogenesisIEAbiological_process