Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITB8_HUMAN
Description:integrin, beta 8 [Source:HGNC Symbol;Acc:6163]
Location:chr7 p21.1
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y447TGGKNyAIIKPIntegrin_betaPhosphoSitePlus
S78FISGGsRSERCIntegrin_betaPhosphoSitePlus
S75QEDFIsGGSRSIntegrin_betaPhosphoSitePlus
S468IHRNCsCQCEDIntegrin_betaPhosphoSitePlus

Dephosphorylation site
ITB8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000222573C607YCOSMICMelanoma
ENSP00000222573G476*BIOMARTBrain Cancer21930507, 21930502

Differential expressed protein
ITB8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ITB8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CO4A1_HUMANITB8_HUMANligand -> receptorHPMR
FINC_HUMANITB8_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04512ECM-receptor interaction
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa04510Focal adhesion
hsa04514Cell adhesion molecules (CAMs)
hsa05414Dilated cardiomyopathy
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060674placenta blood vessel developmentTASbiological_process
GO:0001573ganglioside metabolic processIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0004872receptor activityIEAmolecular_function
GO:0008305integrin complexIEAcellular_component
GO:0007155cell adhesionTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007160cell-matrix adhesionIEAbiological_process


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