| UniProt/SwissProt ID: | ITB8_HUMAN |
| Description: | integrin, beta 8 [Source:HGNC Symbol;Acc:6163] |
| Location: | chr7 p21.1 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y447 | TGGKNyAIIKP | Integrin_beta | PhosphoSitePlus |
| S78 | FISGGsRSERC | Integrin_beta | PhosphoSitePlus |
| S75 | QEDFIsGGSRS | Integrin_beta | PhosphoSitePlus |
| S468 | IHRNCsCQCED | Integrin_beta | PhosphoSitePlus |
| Dephosphorylation site |
| ITB8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000222573 | C607Y | COSMIC | Melanoma | ENSP00000222573 | G476* | BIOMART | Brain Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ITB8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ITB8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CO4A1_HUMAN | ITB8_HUMAN | ligand -> receptor | HPMR |
| FINC_HUMAN | ITB8_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05410 | Hypertrophic cardiomyopathy (HCM) |
| hsa04512 | ECM-receptor interaction |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (A |
| hsa04510 | Focal adhesion |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa05414 | Dilated cardiomyopathy |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0060674 | placenta blood vessel development | TAS | biological_process |
| GO:0001573 | ganglioside metabolic process | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0007229 | integrin-mediated signaling pathway | IEA | biological_process |
| GO:0005102 | receptor binding | IEA | molecular_function |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0004872 | receptor activity | IEA | molecular_function |
| GO:0008305 | integrin complex | IEA | cellular_component |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007160 | cell-matrix adhesion | IEA | biological_process |