Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SDC1_HUMAN
Description:syndecan 1 [Source:HGNC Symbol;Acc:10658]
Location:chr2 p24.1
Node attribute:receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y286KDEGSySLEEPHPRD
Y299ANGGAyQKPTKSyndecanPhosphoSitePlus
Y309KQEEFyA____PhosphoSitePlus
Y299ANGGAyQKPTKHPRD
Y309KQEEFHPRD; phosphoELM
Y286KDEGSySLEEPSyndecan; Podoplanin; GlyPhosphoSitePlus

Dephosphorylation site
SDC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000254351R155MCOSMICOvarian Cancer21720365
ENSP00000254351H154YCOSMICOvarian Cancer21720365
ENSP00000254351V25LCOSMICOvarian Cancer21720365
ENSP00000254351G36ACOSMICOvarian Cancer21720365
ENSP00000254351Q237*COSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000370542Pancreatic CancerNormal vs. CancertissueDown0.4316215274
ENSP00000370542Breast CancerMetastasiscell lineDown0.05418729497

Hyperphosphorylation site
SDC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TSP1_HUMANSDC1_HUMANligand -> receptorHPMR
CO1A1_HUMANSDC1_HUMANotherKEGG
TENA_HUMANSDC1_HUMANotherKEGG
COMP_HUMANSDC1_HUMANotherKEGG
FINC_HUMANSDC1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04514Cell adhesion molecules (CAMs)
hsa04512ECM-receptor interaction
hsa05144Malaria

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005925focal adhesionIDAcellular_component
GO:0048627myoblast developmentIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0009986cell surfaceIEAcellular_component
GO:0001948glycoprotein bindingIEAmolecular_function
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0008092cytoskeletal protein bindingIEAmolecular_function
GO:0043202lysosomal lumenTAScellular_component
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0048627myoblast developmentISSbiological_process
GO:0030204chondroitin sulfate metabolic processTASbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0042157lipoprotein metabolic processTASbiological_process
GO:0006027glycosaminoglycan catabolic processTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0043234protein complexIEAcellular_component
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030203glycosaminoglycan metabolic processTASbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0006629lipid metabolic processTASbiological_process
GO:0009636response to toxinIEAbiological_process
GO:0055002striated muscle cell developmentIEPbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0001657ureteric bud developmentIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0042476odontogenesisIEAbiological_process
GO:0006024glycosaminoglycan biosynthetic processTASbiological_process
GO:0051592response to calcium ionIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0051591response to cAMPIEAbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0060009Sertoli cell developmentIEAbiological_process
GO:0042060wound healingIEAbiological_process
GO:0005796Golgi lumenTAScellular_component