Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DCE1_HUMAN
Description:glutamate decarboxylase 1 (brain, 67kDa) [Source:HGNC Symbol;Acc:4092]
Location:chr2 q31.1
Node attribute:ligand; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S571FRMVIsNPAATPhosphoSitePlus; HPRD
T91ARFRRtETDFSPhosphoSitePlus; HPRD
T91ARFRRtETDFSPRKCEHPRD
Y265IMAARyKYFPEPyridoxal_deCPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T91RDARFRRtETDFSNLPPP2CBHPRD
T91RDARFRRtETDFSNLPPP2CAHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000350928Q115HTCGAOvarian Cancer21720365, 18772890
ENSP00000350928Q115HCOSMICOvarian Cancer21720365

Differential expressed protein
DCE1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DCE1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DCE1_HUMANGABR2_HUMANligand -> receptorHPMR
DCE1_HUMANGRM4_HUMANligand -> receptorHPMR
DCE1_HUMANGABR1_HUMANligand -> receptorHPMR
KPCE_HUMANDCE1_HUMANkinase -> substrateHPRD
PP2AB_HUMANDCE1_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANDCE1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00650Butanoate metabolism
hsa01100Metabolic pathways
hsa04940Type I diabetes mellitus
hsa00250Alanine, aspartate and glutamate metabolism
hsa00430Taurine and hypotaurine metabolism
hsa00410beta-Alanine metabolism
hsa04727GABAergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042136neurotransmitter biosynthetic processIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0018352protein-pyridoxal-5-phosphate linkageTASbiological_process
GO:0004351glutamate decarboxylase activityIEAmolecular_function
GO:0030170pyridoxal phosphate bindingIEAmolecular_function
GO:0005622intracellularIDAcellular_component
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0012506vesicle membraneNAScellular_component
GO:0016595glutamate bindingIEAmolecular_function
GO:0019752carboxylic acid metabolic processIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0006540glutamate decarboxylation to succinateTASbiological_process
GO:0016829lyase activityIEAmolecular_function
GO:0047485protein N-terminus bindingIEAmolecular_function
GO:0009449gamma-aminobutyric acid biosynthetic processIEAbiological_process
GO:0006520cellular amino acid metabolic processIEAbiological_process
GO:0061202clathrin-sculpted gamma-aminobutyric acid transporTAScellular_component
GO:0007269neurotransmitter secretionTASbiological_process
GO:0006538glutamate catabolic processTASbiological_process
GO:0016831carboxy-lyase activityIEAmolecular_function


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