Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SIAH1_HUMAN
Description:siah E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:10857]
Location:chr16 q12.1
Node attribute:PPI(source); PPI(target); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2____MsRQTATPhosphoSitePlus
S2QTATHPRD; phosphoELM
Y126CEFRPySCPCPSinaPhosphoSitePlus
S19SKCPPsQRVPAPhosphoSitePlus
T44ALPTGtSKCPPHPRD
T13ALPTGtSKCPPHPRD; phosphoELM
S33KRKEMsRQTATHPRD
Y100LFPCKyASSGCSinaPhosphoSitePlus

Dephosphorylation site
SIAH1_HUMAN do not have dephosphorylation site.

Mutation site
SIAH1_HUMAN do not have mutation site.

Differential expressed protein
SIAH1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SIAH1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
P53_HUMANSIAH1_HUMANotherKEGG
SIAH1_HUMANCYC_HUMANotherKEGG
P53_HUMANSIAH1_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04120Ubiquitin mediated proteolysis
hsa04115p53 signaling pathway
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0006511ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0004842ubiquitin-protein ligase activityISSmolecular_function
GO:0006508proteolysisTASbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:2001244positive regulation of intrinsic apoptotic signaliIMPbiological_process
GO:0042787protein ubiquitination involved in ubiquitin-depenISSbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0030877beta-catenin destruction complexIDAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0043161proteasomal ubiquitin-dependent protein catabolic ISSbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0007399nervous system developmentTASbiological_process
GO:0030163protein catabolic processIDAbiological_process
GO:0051402neuron apoptotic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007283spermatogenesisIEAbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0031648protein destabilizationIEAbiological_process
GO:0005769early endosomeIEAcellular_component
GO:0008022protein C-terminus bindingIEAmolecular_function


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