Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CXCR2_HUMAN
Description:chemokine (C-X-C motif) receptor 2 [Source:HGNC Symbol;Acc:6027]
Location:chr2 q35
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S353FVGSSsGHTSTPhosphoSitePlus; HPRD; phosphoELM
S351PSFVGsSSGHTPhosphoSitePlus; HPRD; phosphoELM
S352SFVGSsSGHTSPhosphoSitePlus; HPRD; phosphoELM
S347KDSRPsFVGSSPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
CXCR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000319635G354WCOSMICLung Cancer

Differential expressed protein
CXCR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CXCR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CXCL3_HUMANCXCR2_HUMANligand -> receptorHPMR
GROA_HUMANCXCR2_HUMANligand -> receptorHPMR
IL8_HUMANCXCR2_HUMANligand -> receptorHPMR
CXCL5_HUMANCXCR2_HUMANligand -> receptorHPMR
CXCL2_HUMANCXCR2_HUMANligand -> receptorHPMR
CXCL7_HUMANCXCR2_HUMANligand -> receptorHPMR
CXCL6_HUMANCXCR2_HUMANligand -> receptorHPMR
CXCR2_HUMANGNAI3_HUMANGPCR -> GproteingpDB
CXCR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
CXCR2_HUMANGNAI2_HUMANGPCR -> GproteingpDB
CXCR2_HUMANGNAI1_HUMANGPCR -> GproteingpDB
CXCL6_HUMANCXCR2_HUMANotherKEGG
IL8_HUMANCXCR2_HUMANotherKEGG
GROA_HUMANCXCR2_HUMANotherKEGG
CXCL7_HUMANCXCR2_HUMANotherKEGG
CXCL2_HUMANCXCR2_HUMANotherKEGG
CXCL3_HUMANCXCR2_HUMANotherKEGG
CXCL5_HUMANCXCR2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04062Chemokine signaling pathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009986cell surfaceIDAcellular_component
GO:0016494C-X-C chemokine receptor activityIDAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006954inflammatory responseTASbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0038112interleukin-8-mediated signaling pathwayIDAbiological_process
GO:0016020membraneIDAcellular_component
GO:0031623receptor internalizationIDAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0042629mast cell granuleIDAcellular_component
GO:0004871signal transducer activityIDAmolecular_function
GO:0007166cell surface receptor signaling pathwayIDAbiological_process
GO:0006935chemotaxisIDAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007200phospholipase C-activating G-protein coupled recepIDAbiological_process
GO:0005622intracellularIDAcellular_component
GO:0006968cellular defense responseIDAbiological_process
GO:0019959interleukin-8 bindingIPImolecular_function
GO:0030593neutrophil chemotaxisIEAbiological_process
GO:0002407dendritic cell chemotaxisTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007165signal transductionIDAbiological_process
GO:0042119neutrophil activationIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0004918interleukin-8 receptor activityIEAmolecular_function
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process


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