| UniProt/SwissProt ID: | CXCR1_HUMAN |
| Description: | chemokine (C-X-C motif) receptor 1 [Source:HGNC Symbol;Acc:6026] |
| Location: | chr2 q35 |
| Node attribute: | PPI(source); GPCR; receptor; PPI(target) |
| Phosphorylation site |
| CXCR1_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| CXCR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000295683 | W161L | COSMIC | Lung Cancer | 20668451 | ENSP00000295683 | P302T | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| CXCR1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CXCR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IL8_HUMAN | CXCR1_HUMAN | ligand -> receptor | HPMR |
| CXCL6_HUMAN | CXCR1_HUMAN | ligand -> receptor | HPMR |
| CXCR1_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| CXCR1_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| CXCR1_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| CXCR1_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| IL8_HUMAN | CXCR1_HUMAN | other | KEGG |
| CXCR1_HUMAN | ADA10_HUMAN | other | KEGG |
| CXCL6_HUMAN | CXCR1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04062 | Chemokine signaling pathway |
| hsa04144 | Endocytosis |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori i |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006954 | inflammatory response | TAS | biological_process |
| GO:0038112 | interleukin-8-mediated signaling pathway | IDA | biological_process |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0007166 | cell surface receptor signaling pathway | IDA | biological_process |
| GO:0019959 | interleukin-8 binding | IPI | molecular_function |
| GO:0004950 | chemokine receptor activity | TAS | molecular_function |
| GO:0002407 | dendritic cell chemotaxis | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0006935 | chemotaxis | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0070098 | chemokine-mediated signaling pathway | TAS | biological_process |
| GO:0004918 | interleukin-8 receptor activity | IDA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0031623 | receptor internalization | IDA | biological_process |