Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADA10_HUMAN
Description:ADAM metallopeptidase domain 10 [Source:HGNC Symbol;Acc:188]
Location:chr15 q21.3
Node attribute:PPI(source); cleavage(source); PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S605KKMDPsTCASTPhosphoSitePlus
T719KPLPGtLKRRRPhosphoSitePlus
T214LRKKRtTSAEKPhosphoSitePlus
S705SVHTPsSNPKLPhosphoSitePlus
Y741RPRESyQMGHMPhosphoSitePlus
S740QRPREsYQMGHPhosphoSitePlus

Dephosphorylation site
ADA10_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000260408H176YCOSMICMelanoma21618342
ENSP00000260408G264RCOSMICMelanoma21499247
ENSP00000260408G334ECOSMICMelanoma
ENSP00000260408K299MCOSMICOvarian Cancer21720365

Differential expressed protein
ADA10_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADA10_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ADA10_HUMANDLL1_HUMANcleavageNetPath
ADA10_HUMANHBEGF_HUMANotherKEGG
CXCR1_HUMANADA10_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa05120Epithelial cell signaling in Helicobacter pylori i

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051089constitutive protein ectodomain proteolysisIDAbiological_process
GO:0005634nucleusISScellular_component
GO:0014069postsynaptic densityIEAcellular_component
GO:0007220Notch receptor processingTASbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0019901protein kinase bindingISSmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007267cell-cell signalingNASbiological_process
GO:0042117monocyte activationIMPbiological_process
GO:0007219Notch signaling pathwayISSbiological_process
GO:0004175endopeptidase activityISSmolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0008237metallopeptidase activityIDAmolecular_function
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0007229integrin-mediated signaling pathwayNASbiological_process
GO:0006509membrane protein ectodomain proteolysisIDAbiological_process
GO:0007162negative regulation of cell adhesionIDAbiological_process
GO:0034612response to tumor necrosis factorIDAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0004222metalloendopeptidase activityIMPmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0005798Golgi-associated vesicleIDAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005737cytoplasmISScellular_component
GO:0005178integrin bindingNASmolecular_function
GO:0004175endopeptidase activityIEAmolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0042803protein homodimerization activityISSmolecular_function
GO:0005102receptor bindingNASmolecular_function
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0006468protein phosphorylationISSbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0010820positive regulation of T cell chemotaxisIMPbiological_process
GO:0012505endomembrane systemIEAcellular_component
GO:0008237metallopeptidase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0051088PMA-inducible membrane protein ectodomain proteolyIMPbiological_process
GO:0001701in utero embryonic developmentISSbiological_process
GO:0030307positive regulation of cell growthIMPbiological_process
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0016021integral to membraneNAScellular_component