Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CXA1_HUMAN
Description:gap junction protein, alpha 1, 43kDa [Source:HGNC Symbol;Acc:4274]
Location:chr6 q22.31
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S282PLSPMsPPGYKMAPK7HPRD
S282PLSPMsPPGYKMAPK3HPRD
Y247GKSDPyHATSGPhosphoSitePlus; phosphoELM; RegPhos
T250DPYHAtSGALSPhosphoSitePlus
S330STISNsHAQPFCK1dRegPhos; SysPTM
S368PSSRAsSRASSPRKCAHPRD
S368PSSRAsSRASSPRKCGHPRD
S325MGQAGsTISNSCSNK1DHPRD
S262AKDCGsQKYAYPhosphoSitePlus; phosphoELM; RegPhos
S368PSSRAsSRASSPhosphoSitePlus
S255TSGALsPAKDCPhosphoSitePlus; phosphoELM; RegPhos
S344DDNQNsKKLAAPhosphoSitePlus
S328AGSTIsNSHAQCSNK1DHPRD
S368PSSRAsSRASSPKC_epsilonphosphoELM
S251PYHATsGALSPPhosphoSitePlus; HPRD
S328AGSTIsNSHAQCK1dRegPhos
S282PLSPMsPPGYKMAPK1HPRD
Y265CGSQKyAYFNGSRCHPRD; RegPhos
S282PLSPMsPPGYKPhosphoSitePlus; phosphoELM; RegPhos
Y313QNWANySAEQNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S279PTAPLsPMSPPPhosphoSitePlus; phosphoELM; RegPhos
Y247GKSDPyHATSGSRCHPRD; RegPhos
Y265CGSQKyAYFNGPhosphoSitePlus
S365DQRPSsRASSRPhosphoSitePlus; HPRD; RegPhos; SysPTM
S314NWANYsAEQNRPhosphoSitePlus; HPRD; RegPhos
S282PLSPMsPPGYKErk1RegPhos
S282PLSPMsPPGYKErk2RegPhos
S297DRNNSsCRNYNConnexin43PhosphoSitePlus
S368PSSRAsSRASSPRKCBHPRD
S368PSSRAsSRASSPKCe(PKC epsilonRegPhos
Y286MSPPGyKLVTGPhosphoSitePlus
S306YNKQAsEQNWAConnexin43PhosphoSitePlus; SysPTM
T290GYKLVtGDRNNPhosphoSitePlus
S330STISNsHAQPFPhosphoSitePlus; RegPhos; SysPTM
S328AGSTIsNSHAQPhosphoSitePlus; RegPhos
T326GQAGStISNSHPhosphoSitePlus; HPRD; RegPhos; SysPTM
S244RVKGKsDPYHAPhosphoSitePlus
S279PTAPLsPMSPPErk1RegPhos
Y137IKKFKyGIEEHPhosphoSitePlus
Y301SSCRNyNKQASConnexin43PhosphoSitePlus
Y267SQKYAyFNGCSPhosphoSitePlus
S255TSGALsPAKDCErk5RegPhos
S255TSGALsPAKDCErk1RegPhos
S255TSGALsPAKDCErk2RegPhos
S368PSSRAsSRASSPKCbRegPhos
S368PSSRAsSRASSPKCaRegPhos
S368PSSRAsSRASSPKCgRegPhos
S306YNKQAsEQNWAHPRD; RegPhos; SysPTM
S325MGQAGsTISNSPhosphoSitePlus
S373SSRASsRPRPDHPRD; RegPhos
S325MGQAGsTISNSCK1dRegPhos
S330STISNsHAQPFCSNK1DHPRD; SysPTM
S282PLSPMsPPGYKErk5RegPhos
S255TSGALsPAKDCMAPK7HPRD
S255TSGALsPAKDCMAPK1HPRD
S255TSGALsPAKDCMAPK3HPRD
S369SSRASsRASSRHPRD; RegPhos
S296GDRNNsSCRNYConnexin43PhosphoSitePlus
S279PTAPLsPMSPPMAPK3HPRD

Dephosphorylation site
CXA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282561V289LTCGAOvarian Cancer21720365, 18772890
ENSP00000282561Y17CBIOMARTBreast Cancer21930507, 21930502
ENSP00000282561D360ECOSMICOvarian Cancer21720365
ENSP00000282561V289LCOSMICOvarian Cancer21720365
ENSP00000282561D360ETCGAOvarian Cancer21720365, 18772890

Differential expressed protein
CXA1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CXA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCXA1_HUMANkinase -> substrateRegPhos
MK01_HUMANCXA1_HUMANkinase -> substrateHPRD
KPCA_HUMANCXA1_HUMANkinase -> substrateHPRD
KPCB_HUMANCXA1_HUMANkinase -> substrateHPRD
KPCG_HUMANCXA1_HUMANkinase -> substrateHPRD
MK03_HUMANCXA1_HUMANkinase -> substrateHPRD
KC1D_HUMANCXA1_HUMANkinase -> substrateHPRD
MK07_HUMANCXA1_HUMANkinase -> substrateHPRD
SRC_HUMANCXA1_HUMANkinase -> substrateRegPhos
SP1_HUMANCXA1_HUMANTF -> target geneTRANSFAC
JUN_HUMANCXA1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa04540Gap junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010643cell communication by chemical couplingIEAbiological_process
GO:0086014regulation of atrial cardiac muscle cell action poTASbiological_process
GO:0051924regulation of calcium ion transportIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005921gap junctionIEAcellular_component
GO:0003294atrial ventricular junction remodelingIEAbiological_process
GO:0030054cell junctionIEAcellular_component
GO:0004871signal transducer activityIMPmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0051259protein oligomerizationIEAbiological_process
GO:0048514blood vessel morphogenesisIEAbiological_process
GO:0007267cell-cell signalingIEAbiological_process
GO:0045732positive regulation of protein catabolic processIEAbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0005916fascia adherensIEAcellular_component
GO:0045216cell-cell junction organizationIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0061337cardiac conductionIEAbiological_process
GO:2000810regulation of tight junction assemblyIEAbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0048487beta-tubulin bindingIEAmolecular_function
GO:0097110scaffold protein bindingIEAmolecular_function
GO:0006810transportTASbiological_process
GO:0010644cell communication by electrical couplingIEAbiological_process
GO:0046850regulation of bone remodelingIEAbiological_process
GO:0005771multivesicular bodyIEAcellular_component
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0060156milk ejectionIEAbiological_process
GO:0060373regulation of ventricular cardiac muscle cell membIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016044cellular membrane organizationTASbiological_process
GO:0060174limb bud formationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006936muscle contractionTASbiological_process
GO:0005768endosomeIEAcellular_component
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0005769early endosomeIEAcellular_component
GO:0007512adult heart developmentIEAbiological_process
GO:0005741mitochondrial outer membraneIEAcellular_component
GO:0010644cell communication by electrical couplingIDAbiological_process
GO:0035050embryonic heart tube developmentIEAbiological_process
GO:0015867ATP transportIEAbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0060371regulation of atrial cardiac muscle cell membrane IEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0043403skeletal muscle tissue regenerationIEAbiological_process
GO:0009268response to pHIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0005882intermediate filamentIEAcellular_component
GO:0008016regulation of heart contractionIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0030165PDZ domain bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0010232vascular transportIEAbiological_process
GO:0043292contractile fiberIEAcellular_component
GO:0005794Golgi apparatusISScellular_component
GO:0045121membrane raftISScellular_component
GO:0048812neuron projection morphogenesisIEAbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0007154cell communicationIEAbiological_process
GO:0005764lysosomeIEAcellular_component
GO:0005770late endosomeIEAcellular_component
GO:0016264gap junction assemblyTASbiological_process
GO:0005243gap junction channel activityIEAmolecular_function
GO:0005911cell-cell junctionIEAcellular_component
GO:0030500regulation of bone mineralizationIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005886plasma membraneISScellular_component
GO:0005102receptor bindingIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005921gap junctionISScellular_component
GO:0007165signal transductionIMPbiological_process
GO:0060307regulation of ventricular cardiac muscle cell membIEAbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0014704intercalated discIEAcellular_component
GO:0002070epithelial cell maturationIEAbiological_process
GO:0002088lens development in camera-type eyeIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0016324apical plasma membraneIEAcellular_component
GO:0030660Golgi-associated vesicle membraneTAScellular_component
GO:0045844positive regulation of striated muscle tissue deveIEAbiological_process
GO:0005243gap junction channel activityIDAmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0015075ion transmembrane transporter activityTASmolecular_function
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0016328lateral plasma membraneIEAcellular_component
GO:0014704intercalated discISScellular_component
GO:0034220ion transmembrane transportTASbiological_process
GO:0005922connexon complexIEAcellular_component
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0007267cell-cell signalingTASbiological_process