| UniProt/SwissProt ID: | PTN3_HUMAN |
| Description: | protein tyrosine phosphatase, non-receptor type 3 [Source:HGNC Symbol;Acc:9655] |
| Location: | chr9 q31.3 |
| Node attribute: | phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S359 | MRRSLsVEHLE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S367 | HLETKsLPSRS | PhosphoSitePlus; HPRD; phosphoELM | |
| S395 | KPRHSsADNLA | HPRD; phosphoELM | |
| S469 | APGSCsPDGVD | PhosphoSitePlus | |
| Y324 | NVLSQyWTMGS | PhosphoSitePlus; HPRD | |
| S394 | RKPRHsSADNL | HPRD; phosphoELM | |
| S835 | SLRVDsEPVLV | Y_phosphatase | PhosphoSitePlus |
| Y244 | AGVAVyRKYIC | FERM_C | PhosphoSitePlus |
| S835 | SLRVDsEPVLV | phosphoELM | |
| S372 | SLPSRsPPITP | PhosphoSitePlus; HPRD; phosphoELM | |
| S370 | TKSLPsRSPPI | HPRD; phosphoELM | |
| S459 | SSSSVsPSSNA | PhosphoSitePlus | |
| T376 | RSPPItPNWRS | PhosphoSitePlus; HPRD; phosphoELM | |
| S455 | LTQKSsSSVSP | PhosphoSitePlus | |
| S381 | TPNWRsPRLRH | PhosphoSitePlus; HPRD; phosphoELM | |
| S357 | PAMRRsLSVEH | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| PTN3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363667 | R385W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000378308 | R371C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363667 | G768S | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000363667 | E193Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000378308 | G768S | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000378308 | E193Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000363667 | R371C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000378308 | R385W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000363667 | H812L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000378308 | H812L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000378308 | D811E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363667 | D811E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000378308 | F578C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363667 | F578C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PTN3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTN3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PTN3_HUMAN | CD3Z_HUMAN | phosphatase -> substrate | NetPath |
| PTN3_HUMAN | TERA_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| PTN3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0035335 | peptidyl-tyrosine dephosphorylation | TAS | biological_process |
| GO:0006470 | protein dephosphorylation | IDA | biological_process |
| GO:0009898 | internal side of plasma membrane | IDA | cellular_component |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0001784 | phosphotyrosine binding | IPI | molecular_function |
| GO:0008092 | cytoskeletal protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0045930 | negative regulation of mitotic cell cycle | IDA | biological_process |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase acti | IEA | molecular_function |
| GO:0016311 | dephosphorylation | IEA | biological_process |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051045 | negative regulation of membrane protein ectodomain | IMP | biological_process |
| GO:0051117 | ATPase binding | IPI | molecular_function |