Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BKRB2_HUMAN
Description:bradykinin receptor B2 [Source:HGNC Symbol;Acc:1030]
Location:chr14 q32.2
Node attribute:receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y177RWAKLySLVIWSRCphosphoELM
S373GTLRTsISVERPKCa(PKC alphaRegPhos
S373GTLRTsISVERBARK2RegPhos
S373GTLRTsISVERPKC_alphaphosphoELM
S375LRTSIsVERQIGPRK4(GRK4RegPhos
S373GTLRTsISVERPRKCDHPRD
S375LRTSIsVERQIBARK1RegPhos
S375LRTSIsVERQIBARK2RegPhos
S366IQMENsMGTLRADRBK2HPRD
S366IQMENsMGTLRADRBK1HPRD
S366IQMENsMGTLRGRK4HPRD
S366IQMENsMGTLRGRK6HPRD
S366IQMENsMGTLRBARK1RegPhos
S373GTLRTsISVERBARK1RegPhos
S373GTLRTsISVERGPRK4RegPhos
S373GTLRTsISVERGPRK6RegPhos
S375LRTSIsVERQIGRK-4phosphoELM
S373GTLRTsISVERADRBK2HPRD
S373GTLRTsISVERADRBK1HPRD
Y347KSWEVyQGVCQSRCphosphoELM
Y347KSWEVyQGVCQSrcRegPhos
Y332LNPLVyVIVGKTM; 7tm_1PhosphoSitePlus
S373GTLRTsISVERPKCdRegPhos
Y177RWAKLySLVIWTM; 7tm_1PhosphoSitePlus
S373GTLRTsISVERGRK-4phosphoELM
T162LALVKtMSMGR7tm_1PhosphoSitePlus
S373GTLRTsISVERGPRK5RegPhos
S366IQMENsMGTLRPhosphoSitePlus
S373GTLRTsISVERPhosphoSitePlus
S375LRTSIsVERQIADRBK2HPRD
S375LRTSIsVERQIADRBK1HPRD
S366IQMENsMGTLRGRK5HPRD
S178WAKLYsLVIWGTM; 7tm_1PhosphoSitePlus
S373GTLRTsISVERGPRK4(GRK4RegPhos
S366IQMENsMGTLRGPRK4RegPhos
S366IQMENsMGTLRGPRK6RegPhos
S375LRTSIsVERQIGPRK6RegPhos
S375LRTSIsVERQIGPRK5RegPhos
S375LRTSIsVERQIGPRK4RegPhos
Y177RWAKLySLVIWSrcRegPhos
S375LRTSIsVERQIGRK4HPRD
S375LRTSIsVERQIGRK5HPRD
S375LRTSIsVERQIGRK6HPRD
S366IQMENsMGTLRGPRK4(GRK4RegPhos
S366IQMENsMGTLRGPRK5RegPhos
T369ENSMGtLRTSIHPRD; RegPhos
Y332LNPLVyVIVGKphosphoELM; RegPhos
S17SVREDsVPTTAPhosphoSitePlus
Y156VSIDRyLALVKHPRD; RegPhos
S375LRTSIsVERQIPhosphoSitePlus
S373GTLRTsISVERPKC_groupphosphoELM; RegPhos
S366IQMENsMGTLRGRK-4phosphoELM
S358KGGCRsEPIQMHPRD; RegPhos
Y347KSWEVyQGVCQPhosphoSitePlus; HPRD; RegPhos
S366IQMENsMGTLRBARK2RegPhos
S373GTLRTsISVERGRK5HPRD
S373GTLRTsISVERGRK4HPRD
S373GTLRTsISVERGRK6HPRD

Dephosphorylation site
BKRB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000450482G388ECOSMICOvarian Cancer21720365
ENSP00000307713I361FCOSMICOvarian Cancer21720365
ENSP00000307713W386*COSMICBreast Cancer20668451
ENSP00000307713I361FTCGAOvarian Cancer21720365, 18772890
ENSP00000450482I361FTCGAOvarian Cancer21720365, 18772890
ENSP00000307713R196QTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000450482W386*COSMICBreast Cancer20668451
ENSP00000450482L64FCOSMICSkin Cancer21984974
ENSP00000307713L64FCOSMICSkin Cancer21984974
ENSP00000450482R196QTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000450482I361FCOSMICOvarian Cancer21720365
ENSP00000307713G388ECOSMICOvarian Cancer21720365
ENSP00000450482G388ETCGAOvarian Cancer21720365, 18772890
ENSP00000307713G388ETCGAOvarian Cancer21720365, 18772890

Differential expressed protein
BKRB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BKRB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KNG1_HUMANBKRB2_HUMANligand -> receptorHPMR
GRK4_HUMANBKRB2_HUMANkinase -> substrateRegPhos
KPCA_HUMANBKRB2_HUMANkinase -> substrateRobert H Newman (2013)
ARBK2_HUMANBKRB2_HUMANkinase -> substrateRegPhos
ARBK1_HUMANBKRB2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANBKRB2_HUMANkinase -> substrateRegPhos
GRK6_HUMANBKRB2_HUMANkinase -> substrateRegPhos
KPCD_HUMANBKRB2_HUMANkinase -> substrateHPRD
GRK5_HUMANBKRB2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04961Endocrine and other factor-regulated calcium reabs
hsa04020Calcium signaling pathway
hsa04610Complement and coagulation cascades
hsa05142Chagas disease (American trypanosomiasis)
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004947bradykinin receptor activityIDAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0009651response to salt stressIEAbiological_process
GO:0050482arachidonic acid secretionIDAbiological_process
GO:0033137negative regulation of peptidyl-serine phosphorylaIEAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0006939smooth muscle contractionICbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0008015blood circulationNASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0005768endosomeIDAcellular_component
GO:0019229regulation of vasoconstrictionICbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0002020protease bindingIPImolecular_function
GO:0006954inflammatory responseICbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0004435phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0007204elevation of cytosolic calcium ion concentrationTASbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0031702type 1 angiotensin receptor bindingIPImolecular_function
GO:0043114regulation of vascular permeabilityICbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function


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