Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRK4_HUMAN
Description:G protein-coupled receptor kinase 4 [Source:HGNC Symbol;Acc:4543]
Location:chr4 p16.3
Node attribute:effector; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S24GYGKKsGRSKKPhosphoSitePlus
S485DIEQFsVVKGIPhosphoSitePlus

Dephosphorylation site
GRK4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000381129S569TCOSMICGastric Cancer21097718
ENSP00000381129D94ECOSMICHead and Neck Cancer21984974

Differential expressed protein
GRK4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRK4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNA11_HUMANGRK4_HUMANGprotein -> effectorgpDB
GRK4_HUMANBKRB2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05032Morphine addiction
hsa04062Chemokine signaling pathway
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030425dendriteIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004703G-protein coupled receptor kinase activityIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0002031G-protein coupled receptor internalizationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0005938cell cortexIEAcellular_component
GO:0008277regulation of G-protein coupled receptor protein sTASbiological_process
GO:0002029desensitization of G-protein coupled receptor protIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0050254rhodopsin kinase activityIEAmolecular_function
GO:0031623receptor internalizationIDAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function


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