Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GTR1_HUMAN
Description:solute carrier family 2 (facilitated glucose transporter), member 1 [Source:HGNC Symbol;Acc:11005]
Location:chr1 p34.2
Node attribute:PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S118SKLGKsFEMLISugar_trPhosphoSitePlus
T258REKKVtILELFSugar_trPhosphoSitePlus
S226ENRAKsVLKKLSugar_trPhosphoSitePlus
S473RQGGAsQSDKTPhosphoSitePlus; HPRD
T478SQSDKtPEELFPhosphoSitePlus; HPRD
S490PLGADsQV___PhosphoSitePlus
S465FDEIAsGFRQGHPRD
S465FDEIAsGFRQGSugar_trPhosphoSitePlus
S490PLGADsHPRD; phosphoELM
T234KKLRGtADVTHSugar_trPhosphoSitePlus
S118SKLGKsFEMLIHPRD

Dephosphorylation site
GTR1_HUMAN do not have dephosphorylation site.

Mutation site
GTR1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000416293Hepatocellular CarcinomaNormal vs. Cancercell lineUp7.518646787
ENSP00000416293Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3418646787
ENSP00000416293Oral CancerNormal vs. CancertissueUp2.719297561
ENSP00000416293Breast CancerTreatment (mitoxantrone-sensitive vs. mitoxantrone-resistant)cell lineDown0.2516335961

Hyperphosphorylation site
GTR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AAKG2_HUMANGTR1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04976Bile secretion
hsa04920Adipocytokine signaling pathway
hsa05211Renal cell carcinoma
hsa05166HTLV-I infection
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033300dehydroascorbic acid transporter activityIEAmolecular_function
GO:0019852L-ascorbic acid metabolic processTASbiological_process
GO:0022891substrate-specific transmembrane transporter activIEAmolecular_function
GO:0055085transmembrane transportTASbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0008645hexose transportTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0055056D-glucose transmembrane transporter activityIEAmolecular_function
GO:0005355glucose transmembrane transporter activityTASmolecular_function
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0042470melanosomeIEAcellular_component
GO:0016020membraneTAScellular_component
GO:0031982vesicleIEAcellular_component
GO:0006112energy reserve metabolic processTASbiological_process
GO:0006766vitamin metabolic processTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0050796regulation of insulin secretionTASbiological_process
GO:0001939female pronucleusIEAcellular_component
GO:0006970response to osmotic stressIEAbiological_process
GO:0042149cellular response to glucose starvationIEAbiological_process
GO:0070837dehydroascorbic acid transportIEAbiological_process
GO:0015758glucose transportIEAbiological_process
GO:0015758glucose transportTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005911cell-cell junctionIEAcellular_component
GO:0042908xenobiotic transportIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0006767water-soluble vitamin metabolic processTASbiological_process
GO:0005901caveolaIEAcellular_component
GO:0030496midbodyIDAcellular_component
GO:0019900kinase bindingIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0022857transmembrane transporter activityIEAmolecular_function
GO:0042910xenobiotic transporter activityIEAmolecular_function
GO:0005355glucose transmembrane transporter activityIEAmolecular_function


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